Gastroprotective Effect of Ethanolic Extract ofCurcuma xanthorrhizaLeaf against Ethanol-Induced Gastric Mucosal Lesions inSprague-DawleyRats

Abstract

Herbal medicines appeared promising in prevention of many diseases. This study was conducted to investigate the gastroprotective effect of Curcuma xanthorrhiza leaf in the rats induced gastric ulcer by ethanol. Normal and ulcer control received carboxymethycellulose (5 mL/kg) orally, positive control was administered with 20 mg/kg omeprazole (reference drug) and 2 groups were received 250 mg/kg and 500 mg/kg of the leaf extract, respectively. To induce of gastric ulcers formation, ethanol (5 mL/kg) was given orally to all groups except normal control. Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers. Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased. Histology observation showed less edema and leucocytes infiltration as compared with the ulcer control which exhibited severe gastric mucosa injury. Furthermore, the leaf extract elevated the mucus weight, level of prostaglandin E2 and superoxide dismutase. The extract also reduced malondialdehyde amount significantly. Results showed leaf extract of Curcuma xanthorrhiza can enhanced the gastric protection and sustained the integrity of gastric mucosa structure. Acute toxicity test did not showed any sign of toxicity (2 g/kg and 5 g/kg).

Antioxidant and anti-inflammatory activities contribute to the prophylactic effect of semi-purified fractions obtained from the crude methanol extract of Muntingia calabura leaves against gastric ulceration in rats

“…Thus, the bicarbonate secretion was reduced while mucus production was increased. In the histological evaluation, acute ulcers were characterized by the presence of hemorrhage, necrosis and granulation tissue, while the chronic ulcers show the presence of granulation tissue at the base and disruption of muscularis propria (Rahim et al, 2014). Histological results of the present study confirm the severe microscopic damages to the mucosal layer caused by ethanol.…”

Gastroprotective Effect of Hydro-Alcoholic Extract of Polygonum bistorta Lin Root in Indomethacin- Induced Gastric Ulcers in Sprague Dawley Rats

“…20 Catalase and SOD are essential to the body in order to discharge the harmful ROS from the cellular environment. 21 The present study showed that mean SOD and catalase levels were significantly increased in extract treated-500 group-III, extract treated-1000 group-IV and standard drug treated group-V as compared to that decreased in ulcer control group-II rats. HEPB is free from toxic substances and is a safe source of antioxidants.…”

“…HEPB is free from toxic substances and is a safe source of antioxidants. 21 These results suggested the possible involvement of endogenous antioxidants in the experimental effect of HEPB in gastric ulcer. The gastroprotective effect of HEPB could be due to the presence of phenolics present in the extract which was found to be 4378 µg GAE/ g dried extract of HEPB as phenolics possess antioxidant potential.…”

Medicinal plants with gastroprotective potential

“…However, among the different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus), Polygonum minus has potentially better inhibition percentage on ulcer area. Another study showed the antiulcer activity of Curcuma xanthorrhiza ethanolic leaf extract against ethanol-induced gastric ulcerative lesions in rats (Rahim et al, 2014).…”