Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats

Oluwabunmi, Ige Janet; Abiola, T

doi:10.4103/2229-516x.149238

Cited by 25 publications

(14 citation statements)

References 12 publications

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“…[ 28 ] Similarly, Oluwabunmi et al . [ 29 ] reported the production of hemorrhages in indomethacin-induced ulcer in rats after 4 h. In the present study, administration of cimetidine (100 mg/kg), camel milk (5 ml/kg), and urine (5 ml/kg) reduced the severity of the gastric mucosa in terms of the formation of hemorrhagic spots by 100, 33.3, and 66.7%, respectively [ Table 3 ]. The positive control model (cimetidine) showed an almost normal gastric mucosa with no hemorrhagic spots observed.…”

Section: Resultssupporting

confidence: 58%

Gastroprotective and ulcer healing effects of camel milk and urine in HCl/EtOH, non-steroidal anti-inflammatory drugs (indomethacin), and water-restraint stress-induced ulcer in rats

Hu¹,

Chang²,

Qing³

et al. 2017

Phcog Mag

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Background:Camel milk has been reportedly used to treat dropsy, jaundice, tuberculosis, and diabetes while camel urine is used to treat diarrhea and cancer. However, there is no scientific evidence on the antiulcer activity of camel milk and urine. Thus, the present is designed to investigate the gastroprotective and ulcer healing effect of camel milk and urine on experimentally induced gastric ulcer models in rats.Materials and Methods:The gastroprotective effect was investigated in HCl/EtOH, water-restraint stress (WRS) and non-steroidal anti-inflammatory drugs (indomethacin)-induced ulcer models while ulcer healing activity was investigated in indomethacin-induced ulcer model. Cimetidine (100 mg/kg) was used as a standard antiulcer drug.Results:Acute toxicity study done up to a dosage of 10 ml/kg of camel milk and urine showed no signs of toxicity and mortality among the rats, indicating the present dosage of 5 ml/kg is safe to be administered to the rats. In the HCl/EtOH model, oral administration of cimetidine (100 mg/kg), camel urine (5 ml/kg), and camel milk (5 ml/kg) significantly (P < 0.05) inhibited gastric lesions by 83.7, 60.5 and 100%, respectively. In the WRS-induced model, cimetidine, and camel urine showed an ulcer inhibition of 100% while camel milk showed an inhibition of 50%. Similarly, in the indomethacin-induced ulcer model, cimetidine, camel milk, and urine showed an ulcer inhibition of 100, 33.3, and 66.7%, respectively. In addition, camel milk and urine also showed a significant (P < 0.05) ulcer healing effect of 100% in indomethacin-induced ulcer model, with no ulcers observed as compared to that of cimetidine, which offers a healing effect of 60.5%.Conclusion:The antiulcer activity of camel milk and urine may be attributed to its cytoprotective mechanism and antioxidant properties.SUMMARY Acute toxicity findings revealed the dosage of 10 ml/kg of camel milk and urine seems no toxic and indicating the dosage of 5 ml/kg is safe to be administered to the ratsOral administration of cimetidine (100 mg/kg), camel urine (5 ml/kg), and camel milk (5 ml/kg) significantly inhibited gastric lesions by 83.7, 60.5 and 100% in the HCl/EtOH experimental modelThe results of this investigation have proven that camel milk and urine showed strong ulcer healing effect in indomethacin-induced gastric damage. Abbreviations used: NSAIDs: Non-steroidal anti-inflammatory drugs, UI: Ulcer index, ANOVA: One-way analysis of variance, WRS: Water-restraint stress, ROS: Reactive oxygen species

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Section: Resultssupporting

confidence: 58%

Gastroprotective and ulcer healing effects of camel milk and urine in HCl/EtOH, non-steroidal anti-inflammatory drugs (indomethacin), and water-restraint stress-induced ulcer in rats

Hu¹,

Chang²,

Qing³

et al. 2017

Phcog Mag

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“…Acute UG was caused in the animals according to the procedure described by Oluwabunmi and Abiola. 17 Briey, the rats were administered with a single oral dose of indomethacin (30 mg kg À1 body weight). The animals were deprived of food for 24 h but had free access to water prior to ulcer induction.…”

Section: Animalsmentioning

confidence: 99%

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

et al. 2019

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“…1-Control group: 0.2 ml saline (1st and 4th day) + 24 hour fasting (5th day) + 1 ml saline (i.p, 6th day) + 6 hours after last administration, sacrification. [11] intraperitoneal (i.p, 6th day) + 6 hours after last administration, sacrification.…”

Section: Experimental Groups and Drug Treatmentsmentioning

confidence: 99%

Gastroprotective effect of tarantula cubensis extract in the indomethacin-induced peptic ulcer model in rats

Çankara

Özmen

Savaş³

et al. 2020

Acta Medica Alanya

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Amaç: Gastrik ülser, endüstrileşmiş dünyada çeşitli faktörler nedeniyle en sık görülen gastrointestinal hastalıktır. Bununla birlikte mide ülseri, gastrointestinal sağlığın korunması için genellikle tercih edilen proton pompa inhibitörleri (PPI) veya antiasitler gibi birçok gastroprotektif farmakolojik ajanın kombine kullanılmasından sonra da nüks edebilmektedir. Bu kombinasyonlardaki beklenmedik olumsuz etkiler doğal ürünleri alternatif bir seçenek haline getirir. Bu nedenle, bu çalışmanın temel amacı, tek bir indometasin (40 mg/kg) ile oluşturulan deneysel peptik ülser modelinde doğal bileşiklerden biri olan Tarantula cubensis (TCE) ekstraktının etkisinin araştırılmasıdır. Yöntemler: İndometazin uygulanmasından önce iki doz TCE (0.2 ml/kg) s.k yoldan uygulanmıştır. Tek doz Indometazin (40 mg/kg) uygulamasından altı saat sonra anestezi altında mide dokusu biyokimyasal ve immünohistokimyasal analiz için çıkarılmıştır. Total antioksidan durum/total oksidan durum (TAS/TOS), prostaglandin E2 (PGE2) ve nükleer faktör kappa-B (NF-κB) düzeyleri doku homojenatlarında ELISA ile belirlenmiştir. Kaspaz-3, siklooksijenaz-2 (COX-2), indüklenebilir nitrik oksit sentaz (iNOS) ve tümör nekroz faktörü-alfa (TNF-α) immünohistokimya ile görüntülenmiştir. Bulgular: TCE ile ön tedavi PGE2 düzeylerini artırdı ve toplam oksidatif durumu (TAS / TOS) azaltmıştır. Ek olarak, TCE indometazin uygulamasına bağlı olarak NF-κB düzeylerindeki artışı hafifletmiştir. Histopatolojik ve immünboyama sonuçları, TCE'nin, indometazin uygulamasının sonuçları olan kaspaz-3, COX-2, iNOS ve TNFα'nın yüksek immünoreaktivitesini azalttığını göstermiştir. Sonuç: Çalışmamız TCE tedavisinin, antioksidan ve antiinflamatuvar etkiler yoluyla indometazine bağlı peptik ülserleri iyileştirdiğini göstermiştir.

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Gastroprotective effect of methanolic extract of Gomphrena celosioides on indomethacin induced gastric ulcer in Wistar albino rats

Cited by 25 publications

References 12 publications

Gastroprotective and ulcer healing effects of camel milk and urine in HCl/EtOH, non-steroidal anti-inflammatory drugs (indomethacin), and water-restraint stress-induced ulcer in rats

Gastroprotective and ulcer healing effects of camel milk and urine in HCl/EtOH, non-steroidal anti-inflammatory drugs (indomethacin), and water-restraint stress-induced ulcer in rats

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

Gastroprotective effect of tarantula cubensis extract in the indomethacin-induced peptic ulcer model in rats

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