Gastroprotective Effect of NaHS Against Mucosal Lesions Induced by Ischemia–Reperfusion Injury in Rat

Abstract

Our findings indicate that a possible mechanism for the gastroprotective effect of H(2)S could be through the decreased mRNA expression and plasma release of proinflammatory cytokines.

Gallic Acid and Cyclosporine Mixture and their Effects on Cardiac Dysfunction Induced by Ischemia/Reperfusion and eNOS/iNOS Expression

“…Expression levels of all genes were normalized against GAPDH expression (internal calibrator for equal RNA template loading and normalization). Using a computerized densitometric system (Image J), 18 bands on the gel were scanned and quantified.…”

Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments

“…In these circumstances, H 2 S may reduce tissue injury and accelerate repair processes (15,36). Ischemia-reperfusion injury in the stomach has been shown to be significantly reduced by pretreatment with an H 2 S donor (43).…”

Hydrogen Sulfide: A Rescue Molecule for Mucosal Defence and Repair

“…The reduced gastric injury observed in the study of Mard et al [10] may have been attributable to effects of H 2 S on any of a number of components of mucosal defence, including bicarbonate secretion [13] and mucosal blood flow [6] (see summary in Table 1). A number of recent studies suggest that the ability of H 2 S to maintain mitochondrial function in the face of challenges such as ischemia may underlie some of the beneficial effects of this mediator.…”

“…In the current issue of this journal, Mard et al [10] report that administration of H 2 S just prior to an episode of ischemia-reperfusion can dose-dependently protect the stomach of the rat from damage. Protection could similarly be afforded through administration of L-cysteine, the precursor for H 2 S synthesis.…”

“…The study of Mard et al [10] focused on ischemiareperfusion injury in the stomach. H 2 S is produced and contributes to mucosal defence throughout the GI tract [5].…”