Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals

Abstract

Ethanolic extract of Cissampelos pareira (L.) Hirsuta (Menispermaceae) roots have been examined in various acute and chronic ulcers in validated experimental models in rats. C. pareira extract of 25-100 mg/kg administered orally, twice daily for 5 days showed a dose-dependent, ulcer-protective effect. The extract demonstrated significant protection against 100% ethanol-(P < 0.05), aspirin-(P < 0.001), cold-restraint stress-(P < 0.01) and pylorus ligation-(P < 0.001) induced acute gastric ulcers in rats. A flavonoid Quercetin, isolated from C. pareira, showed significant antiulcer property (P < 0.05 to P < 0.001) against gastric ulcers in different acute models. In chronic ulcers induced by 50% acetic acid, C. pareira significantly (P < 0.001) reduced the ulcer index with decreased perforations after 5-and 10-day treatment. C. pareira significantly enhanced the defense factors as total hexose and sialic acid while significantly reducing the ulcer index in the lipid peroxidase product malondialdehyde in ethanol-induced ulcers.

Hepatoprotective and antioxidant properties of Justicia gendarusa against CCl4 induced acute hepatic damage in rats.

“…Reduction in the levels of SGOT and SGPT towards the normal range indicates the regeneration of liver cells. Decreased level of total protein might be due to the functional failure of the functional cytochrome p450 complexes [28]. Our results are also consistent with previous results.…”

Potential Health Benefits of Bread Supplemented with Defatted Flaxseeds under Dietary Regimen in Normal and Type 2 Diabetic Subjects.

“…The increase in HDL-Ch levels, observed in the present study, might be due to the stimula- Gupta et al [1993]. In the present study, the elevation of lipid peroxidation in the plasma of diabetic patients (represented by high MDA) compared with normal subjects before dietary treatment suggested exposure of tissue and membranes to damage and the failure of antioxidant defense mechanisms to combat free radicals [Amresh et al, 2007]. The reduction in intake of the antioxidant (vitamins E and C) in all subjects and zinc in diabetic patients at the beginning of the study may participate in the increased oxidative stress that may lead to complications.…”

Antioxidant Activity of White (Morus alba L.) and Black (Morus nigra L.)Berries against CCl4 Hepatotoxic Agent

“…The histological observations support the obtained results from serum enzyme assays. Increasing lipid peroxidation in serum or liver increased tissue damage and failure of antioxidant defence mechanisms to prevent the formation of excessive free radicals [23]. Moreover, destruction MDA and fucosidease activity values (Tables 3 and 4) are in constituent trends with that of histopathological results.…”