Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats

Kamar, Samaa S; Latif, N.; Elrefai, Mohamed Fathi Mohamed; Amin, Shaimaa Nasr

doi:10.5115/acb.20.055

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…The experiment was based on a previously reported method [31]. Five rats were used and the experiments were conducted on ve different days.…”

Section: Rat Fundus Stripmentioning

confidence: 99%

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

Jerah,

Taha,

Farasani

et al. 2024

Preprint

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Chewing khat (Catha edulis) releases cathine and cathinone, which may reduce appetite through an unknown mechanism. This study investigated the peripheral and central effects of fresh leaves and buds of C. edulis water extract (CEWE) on appetite and body weight, using in vivo, ex vivo, and in silico models. Rats of both sexes were used for three different experiments. Serotonin receptors were studied using isolated rat fundus samples and molecular docking. Significant differences in body weight were observed in the CEWE-treated groups compared with the controls over eight weeks. However, plasma leptin and ghrelin levels did not change significantly. The expression of the ghrelin and leptin genes was also unaffected, but the expression of the 5-HT gene decreased with CEWE treatment. CEWE antagonizes 5-HT receptors in isolated rat fundus samples. In silico docking indicated that the khat ligands inhibited 5-HT2C receptors. Cathine and cathinone levels in rat plasma were measured. These findings suggest that the appetite-suppressing role of khat can be attributed to its antagonistic effect on 5-HT receptors. Further research is needed to fully understand the mechanism of action of the khat extract. These findings provide a basis for future studies to validate and expand on these discoveries.

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“…The experiment was based on a previously reported method [31]. Five rats were used and the experiments were conducted on ve different days.…”

Section: Rat Fundus Stripmentioning

confidence: 99%

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

Jerah,

Taha,

Farasani

et al. 2024

Preprint

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Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective

El-kerdasy,

Faruk,

Hassan

et al. 2024

Inflammopharmacol

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Sepia officinalis ink mitigates gastric ulcer via modulation of antioxidant/anti-inflammatory pathways

Sadek

2022

Beni-Suef Univ J Basic Appl Sci

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Background Sepia officinalis ink is a bioactive secondary metabolite rich in melanin granules, which has a wide range of nutritional and therapeutic values and also has been used to prevent various gastrointestinal disorders. Gastric ulcer, the most common gastrointestinal disease, is characterized by severe gastric mucosa damage, and its prevention is currently one of the main goals of clinical and experimental studies. Thus, the present study was focused on evaluating the potential gastroprotective efficacy of Sepia officinalis ink extract (SOIE) against ethanol-induced gastric ulcer in rats. Results The current results revealed that SOIE administration at the two selected doses improved significantly gastric mucosa integrity as indicated by the significant (P < 0.05) amelioration in gastric secretion indices (pH and volume) and the marked decrease in the ulcer index. Moreover, SOIE could counteract the gastric oxidative stress induced by ethanol via a marked decline in malondialdehyde content as well as a significant (P < 0.05) increment in glutathione content and antioxidant enzymes activities (catalase and glutathione-s-transferase). Additionally, SOIE treatment caused a significant (P < 0.05) reduction in gastric nitric oxide content. Respecting morphological and histopathological studies, SOIE treatment at 200 mg/kg body weight caused marked healing of gastric lesions as indicated by no hemorrhagic bands or injuries observed as well as significantly reduced severity score of ulcer. Conclusions SOIE could be used as a promising alternative antiulcerogenic compound to treat severe gastric lesions.

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Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats

Cited by 4 publications

References 54 publications

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

Insights into the Anorexic Potential of Khat: An Integrated in vivo, ex vivo, and in silico Investigation

Rosuvastatin repurposing for prophylaxis against ethanol-induced acute gastric ulceration in rats: a biochemical, histological, and ultrastructural perspective

Sepia officinalis ink mitigates gastric ulcer via modulation of antioxidant/anti-inflammatory pathways

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