Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India

Abstract

BackgroundThe objective of the present study is to evaluate the gastroprotective activity of Paederia foetida L. leaf for gastric ulcer.MethodsThe methanol extract of P. foetida L. leaves at two different dose levels was investigated for gastroprotective potential by using Indomethacin-pylorus ligation, alcohol induced and water immersion stress induced model in rats. In vitro DPPH* radical scavenging activity and western blot analysis of stomach tissue from pylorus ligatures rats were also carried out. HPTLC analysis was done to understand the phyto-pharmacological relationship.ResultsMethanol extract at a dose level of 100 mg/kg and 200 mg/kg body weight showed 72 and 78 % ulcer protection when compared to negative control whereas reference drug shown 82 % protection in Indomethacin-pylorus ligation model. Further, methanol extract also showed protective effect against 70 % v/v ethanol and stress induced gastric ulcer model. About 84 % protection as compared to cimetidine (85 %) was seen in western blot analysis of stomach tissue from pylorus ligatures rats. HPTLC analysis of methanol extract of P. foetida L. confirmed the presence of β-sitosterol. In DPPH* radical scavenging activity, the IC50 value was observed to be 43.52 μg/ml.ConclusionsThese observations established the traditional claim and thus Paederia foetida could be a potent gastroprotective agent for use in future. The gastroprotective activity might be mediated by the Nrf2 mediated antioxidant and anti secretory effects.

Comparative study of the antidiabetic potential ofPaederia foetidatwig extracts and compounds from two different locations in Malaysia

“…Malays use the leaves as ‘nasi ulam’ (rice mixed with a variety of chopped herbs) while native communities of Tripura eat the leaves with dry fish (Chanda et al. 2015). The plant has been used to treat toothaches, dysentery, sores, enterosis, enteromagaly, rhinosis, rheumatism, edema, night blindness and digestive problems such as gastritis, diarrhea and ulceration.…”

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

“…The gastric ulcers are regarded as the most common disease of gastrointestinal tract, but they can be caused by many various factors. Therapy of different disorders with using nonsteroidal anti-inflammatory drugs like indomethacin and excessive consumption of alcohol belong to important ones [ 45 , 134 ]. As pharmaceutical agents are not fully effective and their application may also be connected with development of side effects, an alternative ways of treatment became the subject of research.…”

“…The question of advantage of plant origin extracts over any standard drug is complicated, and a univocal answer is very difficult as in some cases the differences in the influence of the compared agents were strongly dependent on the applied dose [ 45 , 135 ] and studied parameters [ 115 , 129 ].…”

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“…Sometimes this plant is kept as an ornamental plant and has virtue in folk medicine. It is also used as a culinary spice in some traditional cooking in North Eastern and Eastern India [9]. The plant is used in the treatment of gout, vesical calculi, diarrhea, dysentery, piles, and inflammation of the liver and also as an emetic drug.…”