Gastroprotective potential of hydro-alcoholic extract of Pattanga (Caesalpinia sappan Linn.)

Chellappan, David Raj; Purushothaman, Arun K.; Brindha, P.

doi:10.1016/j.jep.2016.07.081

Cited by 11 publications

(11 citation statements)

References 54 publications

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“…LC-MS evaluation was performed using a quadrupole time-of-flight mass spectrometer (QTOF-MS) according to the adopted method of Chellappan et al [30]. The samples were dissolved in 0.01% formic acid and ethanol (1:1, v/v) to obtain a final concentration of 1 mg/mL and then cleaned up using QuEChERS dispersive SPE kit, fat + pigments (Agilent Technology, Santa Clara, CA, USA) before passing through a 0.22 µm membrane filter.…”

Section: Characterization Of Semi-purified Fraction By Lc-qtof-msmentioning

confidence: 99%

Effect of Ethanolic Caesalpinia sappan Fraction on In Vitro Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus

Arjin

Hongsibsong

Pringproa

et al. 2021

Veterinary Sciences

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Porcine reproductive and respiratory syndrome virus (PRRSV) is a major epidemic in pig production, leading to economic losses in the pig industry worldwide. The use of medicinal plants with antiviral properties might be useful help to prevent and control PRRSV outbreaks. Caesalpinia sappan (CS) heartwood is an important herbal ingredient used in Thai folk medicine, possessing various biological activities, including antiviral activity. The present study focuses on the in vitro antiviral activity against PRRSV of a semi-purified fraction of ethanolic CS crude extract using preparative high-performance liquid chromatography. Qualification of the fractions illustrating positive antiviral activity was carried out with liquid chromatography–quadrupole time-of-flight mass spectrometry. The preparative chromatography separated the crude extract into six consecutive fractions, among which the first fraction showed potential antiviral activity by inhibiting PRRSV replication in a MARC-145 monolayer (virus titer 2.75 median tissue culture infective dose (TCID50)/mL (log10) vs. 9.50 median log10 TCID50/mL of the control) at 72 h post-infection, and this fraction included byakangelicin, brazilin, naringenin, and brazilein. These results provide useful information for further study to effectively develop the CS bioactive antiviral compounds against PRRSV as a feed additive or veterinary drug in the pig industry.

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Section: Characterization Of Semi-purified Fraction By Lc-qtof-msmentioning

confidence: 99%

Effect of Ethanolic Caesalpinia sappan Fraction on In Vitro Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus

Arjin

Hongsibsong

Pringproa

et al. 2021

Veterinary Sciences

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“…Caesalpinia sappan L.—widely known as pattanga—has been used in the Ayurveda system of medicine for a long time. The hydroalcoholic extract from C. sappan heartwood is rich in polyphenols, including flavonoids such as brazilin, brazilein, hydroxybrazilin and peonidin-3-galactoside which display an interesting antioxidant activity [ 57 ]. The effectiveness of this extract on ulcer protection was also assayed, being of 92%, 86% and 64% against ethanol, indomethacin and pylorus ligation induced ulcers in Wistar rats, respectively.…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

“…Moreover, the plant extract exhibited cytoprotective effects with 76.82% reduction against indomethacin-induced cytotoxicity at the concentration of 25 µg/mL and showed 63.91% inhibition in H + /K + -ATPase (proton pump) inhibitory assay at 500 µg/mL. Indeed, the authors proposed that the gastroprotective activity of C. sappan heartwood is possibly mediated by cytoprotective and antioxidant mechanisms involving an increase in PGE2 synthesis and a decrease in myeloperoxidase (MPO) levels, conferred by antioxidant phytoconstituents present in the plant [ 57 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

“…The acute toxicity test carried out in rats at two doses (1000 mg/kg or 2000 mg/kg) of ethyl acetate extract from Annona muricata (Annonaceae) leaves showed the safety of this plant and that the oral LD 50 is higher than 2 g/kg, which correlated with the previous results obtained in mice (where LD 50 was 1.67 g/kg) [ 191 ]. No signs of toxicity were observed in rats after using a single dose (2000 mg/kg) of hydroalcoholic extracts from Brassica oleracea (Brassicaceae) [ 192 ] and Caesalpinia sappan (Caesalpiniaceae) [ 57 ], confirming even its in vivo gastroprotective effects in different gastric ulcer models. Although most studies on the acute oral toxicity of plant extracts show no signs of toxicity, in the case of the dichloromethane fraction of Piper tuberculatum (Piperaceae) fruit [ 193 ], following administration of an oral dose of 5000 mg/kg, in mice, respiratory changes, pilomotor erection and reduction in locomotion and passivity were stated 10 min after treatment, resulting in animal death after 4 h. The same dose of this extract administrated i.p.…”

Section: Safety Of Plant Products Used As Antiulcerogenic Agentsmentioning

confidence: 99%

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Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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“…Treatment with C. sappan demonstrated a gastroprotective effect against ethanol, indomethacin, and pylorus ligation-induced ulcer in rats. These effects were mediated by the improved antioxidant status of the gastrointestinal system, mucus secretion, reduced inflammatory mediators, and gastric secretion inhibition, which were related to increased COX expression, PGE 2 synthesis, decreased iNOS expression, and the inhibitory effect on H + /K + ATPase [58].…”

Section: Gastroprotective Plants With Antisecretory Effectsmentioning

confidence: 98%

Herbal Medicines in the Treatment of Dyspepsia: An Overview

et al. 2021

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This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

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Gastroprotective potential of hydro-alcoholic extract of Pattanga (Caesalpinia sappan Linn.)

Cited by 11 publications

References 54 publications

Effect of Ethanolic Caesalpinia sappan Fraction on In Vitro Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus

Effect of Ethanolic Caesalpinia sappan Fraction on In Vitro Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Herbal Medicines in the Treatment of Dyspepsia: An Overview

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