Gastroprotective Therapy

Tolbert, M. Katherine

doi:10.1016/j.cvsm.2020.09.001

Cited by 9 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 20 , 21 H2RAs can inhibit the secretion of gastric acid and pepsin by blocking the binding of H2 receptors in gastric mucosal cells that secrete gastric acid to histamine and other substances, thereby reducing the gastric juice volume and hydrogen ion concentration, and antagonizing the vasodilation effect of histamine, protecting the gastric mucosa. 22 There are currently four generations of such drugs used in clinical practice. The PPIs selected in this study were omeprazole and pantoprazole.…”

Section: Discussionmentioning

confidence: 99%

“…It is currently believed that PPIs, in addition to suppressing gastric acid secretion, may also have anti‐inflammatory and antioxidant effects in the treatment of acid‐related diseases 20,21 . H2RAs can inhibit the secretion of gastric acid and pepsin by blocking the binding of H2 receptors in gastric mucosal cells that secrete gastric acid to histamine and other substances, thereby reducing the gastric juice volume and hydrogen ion concentration, and antagonizing the vasodilation effect of histamine, protecting the gastric mucosa 22 . There are currently four generations of such drugs used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy and safety of the short‐term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI

Wei

Zhuo

et al. 2021

Clinical Translational Sci

View full text Add to dashboard Cite

Combination therapy with platelet inhibitors and acid‐suppressive agents is recommended for patients with acute ST‐segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI), but there remains a paucity of data to evaluate both the efficacy and safety of these combinations. In this prospective study, a total of 170 patients with acute STEMI who underwent PCI were divided into four groups: pantoprazole + ticagrelor, omeprazole + ticagrelor, ranitidine + ticagrelor, and ticagrelor only. The risk of PCI, antithrombotic efficacy, cardiac function, and main end points were evaluated and compared. No significant differences were found in infarction‐related artery perfusion indexes (thrombolysis in myocardial infarction [TIMI], corrected TIMI frame count), the incidence of stent thrombosis after PCI, platelet indicators (platelet count, mean platelet volume, and platelet distribution width), platelet activation (P‐selectin and glycoprotein IIb/IIIa levels), platelet aggregation (thrombelastography indicators, such as ADP% and MAADP), myocardial necrosis biomarker (creatine kinase isoenzyme‐MB and cardiac troponin I) levels, brain natriuretic peptide levels, the incidence of ischemic end point events, and the incidence of other tissue and organ bleeding events among the four groups. The incidence of gastrointestinal (GI) bleeding events in the proton pump‐inhibitor (PPI) group was significantly lower than that in the control group, whereas in the H2 receptor antagonist (H2RA) group it was not significantly different from the control group. The short‐term combination therapy with ticagrelor and PPIs or H2RA is safe and effective in patients with acute STEMI after PCI. In addition, the PPIs combined with ticagrelor could reduce the incidence of GI bleeding events without increasing the incidence of ischemic events.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of the short‐term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI

Wei

Zhuo

et al. 2021

Clinical Translational Sci

View full text Add to dashboard Cite

show abstract

“…Зниження кислотності шлункового соку є важливою стратегією в лікуванні цілої низки гастроінтестинальних захворювань. З цією метою на сьогодні використовують різні методи кислотосупресії, що різняться за механізмом дії та ступенем ефективності [39,40]. Антациди, такі як алюмінію фосфат, карбальдрат, симальдрат тощо, зменшують кислотність шлункового соку шляхом нейтралізації HCl.…”

Section: обговоренняunclassified

The Characteristic of the Gastric Secretion After Gastric Cryodenervation and Cryopreserved Placenta Extract Administration

Кошурба

Hladkykh

Chyzh

et al. 2023

Innov Biosyst Bioeng

View full text Add to dashboard Cite

Background. Peptic ulcer is a prevalent gastrointestinal tract disease worldwide. One of the treatment methods for the indicated pathology is trunk gastric cryodenervation (TGC), the feature of which is the preservation of the regenerative potential of n. vagus. Cryopreserved placenta extract (CPE) caught our attention among modern means capable of stimulating regeneration processes. Objective. We are aimed to characterize the state of gastric secretion after TGC and the application of СPE. Methods. TGC was performed by cryoinfusion on the front and back trunks of the abdominal part of n. vagus. Gastric secretion was studied using the H.A. Shay method. Results. On the 30th day after TGC, a statistically significant (p < 0.001) decrease in the total acidity of gastric juice by 33.7% and a decrease (p < 0.01) in the level of free acidity were observed compared to intact animals. Administration of СPE after TGC resulted in a statistically significant (p < 0.001) decrease in total acidity by 24.2 % and a statistically significant (p < 0.001) decrease in free acidity by 48.7% compared to the parameters of intact rats. This led to a statistically significant (p < 0.001) decrease in the "free/bound acidity" ratio compared to the indicator of intact animals (1.4 ± 0.03 RU) which was higher than the similar ratio observed after esomeprazole usage or TGC. Conclusions. Administration of СPE contributed to the partial regeneration of n. vagus, as indicated by an increase in the level of total acidity to 104.1 ± 4.7 RU and a statistically significant (p < 0.001) decrease in the "free/bound acidity" ratio compared to the indicator of intact animals.

show abstract

“…Gastroprotectants are also widely used by veterinarians, but the number of studies assessing their efficacy in dogs and cats is still limited, as most studies have been conducted in healthy animals ( 9 – 12 ). It has been well documented that adequate suppression of acid secretion improves healing in dogs with gastroduodenal ulceration and erosion (GUE) ( 2 , 11 , 13 , 14 ). PPIs have also shown efficacy for the management of gastroesophageal reflux and esophagitis in dogs ( 15 – 17 ) and in prevention of exercise-induced gastritis in working dogs ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and appropriateness of omeprazole prescription in dogs at a veterinary teaching hospital before and after the publication of the ACVIM consensus statement on the rational administration of gastrointestinal protectants

Sainz,

García-Sancho,

Villaescusa

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

IntroductionOverprescribing of acid suppressants is a common phenomenon in human and small animal patients, leading to potential deleterious gastrointestinal (GI) and non-GI consequences. The impact of consensus statements on veterinary prescribing habits in clinical practice have not been fully evaluated. This study aimed to compare the prescribing habits of the proton pump inhibitor (PPI), omeprazole, in dogs in an academic veterinary teaching hospital before and after the publication of the American College of Veterinary Internal Medicine (ACVIM) consensus statement on rational use of gastrointestinal protectants.MethodsEvaluation of the prescribing habits of omeprazole in dogs during the years 2017 and 2021 was retrospectively compared. These years were selected to reflect a 12-month period prior to and following the publication of the consensus statement. One hundred dogs from each year were randomly selected. Dose, frequency of administration, duration of treatment, concurrent prescription of more than one gastroprotectant and indications for prescribing omeprazole were analyzed.ResultsA significant increase in the cases that received omeprazole q12h (p < 0.0001) or that underwent a tapering dose after ≥4 week-therapy (p > 0.0001) was detected after the publication of the 2018 ACVIM consensus statement. Considering the indications, there was also a significant increase in the appropriate prescription of omeprazole in the second compared to the first period of study (p < 0.0001). Fifteen of 16 clinicians (94%) involved in the prescription of omeprazole indicated that their reading of the consensus statement had changed their clinical practice regarding PPI administration in dogs.DiscussionThese results support the beneficial impact of the ACVIM consensus statement on the judicious prescribing of omeprazole in an academic veterinary hospital. These results should not be extrapolated to first-opinion veterinary practices, and further efforts should be made to ensure that PPIs are prescribed prudently with a clear indication and regular review of the appropriateness of continued administration to minimize possible risks and adverse drug interactions.

show abstract

Gastroprotective Therapy

Cited by 9 publications

References 32 publications

The efficacy and safety of the short‐term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI

The efficacy and safety of the short‐term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI

The Characteristic of the Gastric Secretion After Gastric Cryodenervation and Cryopreserved Placenta Extract Administration

Prevalence and appropriateness of omeprazole prescription in dogs at a veterinary teaching hospital before and after the publication of the ACVIM consensus statement on the rational administration of gastrointestinal protectants

Contact Info

Product

Resources

About