Gastroretentive bilayer film for sustained release of atorvastatin calcium and immediate release of amlodipine besylate: pharmaceutical, pharmacokinetic evaluation, and IVIVC

Porwal, Amit; Dwivedi, Harinath; Pathak, Kamla

doi:10.1080/10837450.2019.1705486

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…However, such limitation arises only as long as the use of films is restricted to their administration into the buccal cavity, which need not be the case. Advances in the development of pharmaceutical films have led to uses not restricted to the buccal cavity [ 32 ], and novel film manufacturing methods [ 23 , 33 ] present great potential for expanded uses of films. Application of other methods for prolonging drug release from films [ 23 , 24 ] will further expand their pharmaceutical usefulness.…”

Section: Discussionmentioning

confidence: 99%

“…Application of other methods for prolonging drug release from films [ 23 , 24 ] will further expand their pharmaceutical usefulness. Moreover, multi-layer films are bound to expand the applications of pharmaceutical films further [ 32 , 34 , 35 , 36 ]. The use of multiple film layers makes it possible to utilize films to deliver drug amounts similar to those contained in traditional tablets and capsules [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Tunable Drug Release Rate Using Modular Oral Dosage Forms

Cano-Vega,

Arango-Salazar,

Pinal

2023

Pharmaceutics

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Oral dosage forms with adjustable drug release profiles were prepared using progesterone (PGR) as a poorly-soluble model drug. The dosage forms were made as stack assemblies of functional modules. The modules were made as PGR-carrying HPMC films cut into wafer-like circular pieces. Two types of modules were used in the study; one exhibited comparatively fast drug release and the other slow release. The fast vs. slow release of each type of film utilized resulted from the grade of HPMC used in each case. Drug loading in the assembly was controlled through the total number of modules. By adjusting the proportions of the two types of modules, it is possible to fine-tune the drug release rate of the multi-layer assemblies to a wide range of profiles, bracketed between a high and low end, corresponding to the inherently fastest or slowest release obtainable with the specific materials and procedures employed. This procedure is suitable for adjusting the spring-and-parachute parameters for enhancing/optimizing the bioavailability of poorly-soluble drugs, and for developing patient-centric formulations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tunable Drug Release Rate Using Modular Oral Dosage Forms

Cano-Vega,

Arango-Salazar,

Pinal

2023

Pharmaceutics

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“…Hydroxypropylmethylcellulose (HPMC) ( Figure 7 C) is a water-soluble semisynthetic derivative of cellulose substituted with methoxy and hydroxypropyl groups [ 90 ]. Diosmin, a drug with poor water-solubility which limits its therapeutic applicability, possesses strong antioxidant activity, along with other interesting effects, including anti-inflammatory, anti-cancer and anti-ulcer activities [ 91 ].…”

Section: Water-soluble Polymers As Auxiliary Agentsmentioning

confidence: 99%

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

et al. 2021

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Cyclodextrins (CDs) are naturally available water-soluble cyclic oligosaccharides widely used as carriers in the pharmaceutical industry for their ability to modulate several properties of drugs through the formation of drug–CD complexes. The addition of an auxiliary substance when forming multicomponent complexes is an adequate strategy to enhance complexation efficiency and to facilitate the therapeutic applicability of different drugs. This review discusses multicomponent complexation using amino acids; organic acids and bases; and water-soluble polymers as auxiliary excipients. Special attention is given to improved properties by including information on the solubility, dissolution, permeation, stability and bioavailability of several relevant drugs. In addition, the use of multicomponent CD complexes to enhance therapeutic drug effects is summarized.

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“…Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patient compliance and flexibility in formulation and cost-effective manufacturing process (Leon Lachman) 1 . Many of the drug delivery systems, available in the market are oral drug delivery type systems pharmaceutical products designed for oral delivery are mainly immediate release type or conventional drug delivery systems, which are designed for immediate release of drug for rapid absorption 2 . Controlled drug delivery systems have been developed which are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the delivery of drug to a tissue.…”

Section: Introductionmentioning

confidence: 99%

Formulation and In-Vitro Evaluation of Amlodipine Besylate Floating Tablets Using Different Polymers

Reddy,

Alagarsamy,

Chandra Bose

2023

Int J Res Rev

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Gastric-retentive amlodipine besylate effervescent tablets have been developed using a variety of hydrophilic polymers. Formulations were developed using different grades of different concentrations of polymer. H. HPMC K4M, HPMC K15M, HPMC K100 and xanthan gum were used as polymeric substances. The formulated mixtures have been subjected to various pre-formulation studies and flow properties, and all formulations show that the powder mixtures have good flow properties. Among all formulations, drug release was delayed for the desired period, H. 12 hours, for the HPMC K100 formulation as a polymer. The dissolution data showed that formulations made with HPMC K100M and xanthan gum as the polymer sustained drug release for the desired period. H. 12 hours at a concentration of 150 mg. On the other hand, in formulations containing HPMC K4M, HPMC K15M as polymer failed to produce the desired drug release. Therefore, the floating drug delivery system of amlodipine using the appropriate amount of appropriate polymer can increase the activity of the drug by prolonging the gastric residence time or decreasing the floating lag time. Keywords: Gastric-retentive, amlodipine besylate, effervescent tablets, HPMC K4M

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Gastroretentive bilayer film for sustained release of atorvastatin calcium and immediate release of amlodipine besylate: pharmaceutical, pharmacokinetic evaluation, and IVIVC

Cited by 8 publications

References 34 publications

Tunable Drug Release Rate Using Modular Oral Dosage Forms

Tunable Drug Release Rate Using Modular Oral Dosage Forms

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

Formulation and In-Vitro Evaluation of Amlodipine Besylate Floating Tablets Using Different Polymers

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