Gastroretentive drug delivery system of carbamazepine: Formulation optimization using simplex lattice design: A technical note

Patel, Dasharath M.; Patel, Nachiket; Pandya, Nitesh N.; Jogani, Pranav D.

doi:10.1208/pt0801011

Cited by 29 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1A shows that the coefficient of 73.1 for X 1 (linear blending term) estimates the contact angle of the pure HPMC film and it was statistically significant (p<0.05). 26) On the other hand, the coefficient of 62.41 for X 2 does not estimate the contact angle of the pure PC film since it had a proportion of HPMC in the total amount of film at HPMC90/PC10. In the regression equation, the positive sign of a factor shows a synergistic effect and vice versa in the negative sign.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

et al. 2017

View full text Add to dashboard Cite

The objectives of this study were to prepare the hydroxypropyl methylcellulose (HPMC)/polycarbophil (PC) mucoadhesive blend film and to investigate the main and interaction effect of HPMC and PC mixtures on the physicochemical and mechanical properties of blend films using a simplex lattice mixture design approach. The cubic and quadratic models were selected to analyze mucoadhesive properties in terms of work of adhesion and maximum detachment force, respectively. It was shown that HPMC/PC blend film had higher mucoadhesive properties than pure HPMC film. The suitable models for analyzing swelling index of blend films at various times were assessed. The puncture strength, % elongation and hydrophilicity of films were also examined. The pure HPMC film displayed more homogeneous and smoother structures compared with the blend film, as observed by scanning electron microscope and atomic force microscopy. Intermolecular hydrogen bonding between HPMC and PC was detected using Fourier transform infrared and X-ray diffraction. Therefore, the blend film shows high potential for use as a buccal delivery system. Key words hydroxypropyl methylcellulose (HPMC); polycarbophil; blend film; mixture design; mucoadhesive film; buccal drug delivery Buccal drug delivery systems have several advantages such as good accessibility, avoiding hepatic first pass metabolism and drug degradation in the gastrointestinal tract.

show abstract

Section: Resultsmentioning

confidence: 99%

“…25,26) However, from Eq. 13 it can be seen that not only did the main factors (X 1 , X 2 ) have an effect on the response variable, but that nonlinear blending terms (X 1 X 2 ,…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Gastroretentive dosage formulations extend the duration of drug action by increasing time over which drug is released, thus increasing dosing intervals and patient compliance. Various gastroretentive techniques, including floating, swelling, high density, and bioadhesive systems, have been explored to increase gastroretention of dosage forms [1].…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of an Oral Floating Matrix Tablet of Salbutamol Sulphate

Kumar¹,

Sahu²,

Sharma³

et al. 2012

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…The in vitro buoyancy (floating behavior) [30] of the tablets was determined by floating lag time (FLT). The tablets were placed in 100 ml beaker containing 0.1 N HCl (pH 1.2).…”

Section: Buoyancy Studiesmentioning

confidence: 99%

Design and Evaluation of Intragastric Buoyant Tablets of Venlafaxine Hydrochloride

Radhika¹,

Nishala²,

Kiruthika³

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate the intragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulations were formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration of drug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent. Methods:The tablets were prepared by direct compression and evaluated for tablet thickness, weight variation, tablet hardness, friability, in vitro buoyancy test, in vitro drug release and Fourier transform infrared spectroscopy. Formulations were evaluated by floating time, floating lag time and in vitro drug release. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of drug.Results: It was found that drug release depends on swelling, erosion, and diffusion, thus following the non-Fickian/anomalous type of diffusion. Formulation F8 was considered as an optimized formulation for gastro retentive floating tablet of venlafaxine hydrochloride. The optimized formulation showed sustained drug release and remained buoyant on the surface of the medium for more than 12 hrs. As the concentration of HPMC K100M increases in the formulation the drug release rate was found to be decreased. The optimized formulation was subjected for the stability studies and was found to be stable as no significant change was observed in various evaluated parameters of the formulation. Conclusion:It can be concluded that floating drug delivery system of venlafaxine hydrochloride can be successfully formulated as an approach to increase gastric residence time, thereby improving its bioavailability.

show abstract

Gastroretentive drug delivery system of carbamazepine: Formulation optimization using simplex lattice design: A technical note

Cited by 29 publications

References 29 publications

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

Design and Evaluation of an Oral Floating Matrix Tablet of Salbutamol Sulphate

Design and Evaluation of Intragastric Buoyant Tablets of Venlafaxine Hydrochloride

Contact Info

Product

Resources

About