Gastroschisis: the cost of an epidemic

Keys, Charles; Drewett, Melanie; Burge, D.M.

doi:10.1016/j.jpedsurg.2007.12.005

Cited by 55 publications

(46 citation statements)

References 10 publications

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“…Our data also confirm the observations from England suggesting that as gastroschisis becomes more common, there are an increasing number of complex patients and thus an increase in annual costs, which is disproportionate to the increase in numbers of cases [24]. Keys et al [24] estimated that the annual cost to the National Health Service of gastroschisis in England and Wales has risen from 3.6 million £ in 1996 to in excess of 15 million £ in 2005.…”

Section: Discussionsupporting

confidence: 88%

“…Keys et al [24] estimated that the annual cost to the National Health Service of gastroschisis in England and Wales has risen from 3.6 million £ in 1996 to in excess of 15 million £ in 2005. Our data show that although there has been a slowing in the prevalence of gastroschisis, the relative number of hospital days attributed to care of neonates with gastroschisis has continued to rise.…”

Section: Discussionmentioning

confidence: 99%

“…Our data show that although there has been a slowing in the prevalence of gastroschisis, the relative number of hospital days attributed to care of neonates with gastroschisis has continued to rise. Because the global health care system is marked by inequalities between as well as within countries, the medical care and public health impact of gastroschisis varies [1,24]. The increasing prevalence of gastroschisis combined with improved medical techniques to reduce morbidity and mortality are also increasing the burden and costs of this anomaly on health systems [1].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of gastroschisis and associated hospital time continue to rise in neonates who are admitted for intensive care

Clark¹,

Walker

Gauderer

2009

Journal of Pediatric Surgery

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of gastroschisis and associated hospital time continue to rise in neonates who are admitted for intensive care

Clark¹,

Walker

Gauderer

2009

Journal of Pediatric Surgery

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“…In view of the sustained, resource-intensive care required in caring for infants born with this birth defect, 23 efforts targeting optimization of care must continue; however there is an accompanying urgent need for a more precise understanding of the risk factors for occurrence, including potential environmental causation factors, which may offer geographic targets for primary prevention strategies. This study is the first to look at geographic distribution of gastroschisis using a national, population-based dataset.…”

Section: Discussionmentioning

confidence: 99%

Spatial variability of gastroschisis in Canada, 2006–2011: An exploratory analysis

Bassil

Yang

Arbour

et al. 2016

Can J Public Health

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OBJECTIVES: Gastroschisis is a serious birth defect of the abdominal wall that is associated with mortality and significant morbidity. Our understanding of the factors causing this defect is limited. The objective of this paper is to describe the geographic variation in incidence of gastroschisis and characterize the spatial pattern of all gastroschisis cases in Canada between 2006 and 2011. Specifically, we aimed to ascertain the differences in spatial patterns between geographic regions and identify significant clusters and their location. METHODS:The study population included 641 gastroschisis cases from the Canadian Pediatric Surgery Network (CAPSNet) database, a population-based dataset of all gastroschisis cases in Canada. Cases were geocoded based on maternal residence. Using Statistics Canada live-birth data as a denominator, the total prevalence of gastroschisis was calculated at the provincial/territorial levels. Random effects logistic models were used to estimate the rates of gastroschisis in each census division. These rates were then mapped using ArcGIS. Cluster detection was performed using Local Indicators of Spatial Association (LISA). RESULTS:There is significant spatial heterogeneity of the rate of gastroschisis across Canada at both the provincial/territorial and census-division level. The Yukon, Northwest Territories and Prince Edward Island have higher overall rates of gastroschisis relative to other provinces/territories. Several census divisions in Alberta, Manitoba, Saskatchewan, Ontario, Northwest Territories and British Columbia demonstrated case "clusters", i.e., focally higher rates in discrete areas relative to surrounding areas. CONCLUSIONS:There is clear evidence of spatial variation in the rates of gastroschisis across Canada. Future research should explore the role of area-based variables in these patterns to improve our understanding of the etiology of gastroschisis.KEY WORDS: Spatial analysis; gastroschisis; cluster analysis; Canada La traduction du résumé se trouve à la fin de l'article.

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“…Delayed maturation of the intestinal pacemaker and smooth muscle cells has been demonstrated in a rat model of gastroschisis [45], which may explain the delayed onset of peristalsis in these patients. However, its etiology has not yet been completely unveiled, and there is no safe and effective treatment for the intestinal dysmotility other than awaiting spontaneous resolution [2,3,46].…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis

Otake¹,

Uchida²,

Koike³

et al. 2012

OJPed

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Purpose: Intestinal dysfunction is a major problem after gastroschisis repair, and causes poor oral intake and poor body weight gain in infants with gastroschisis. Dai-kenchu-to (DKT) is often used in the treatment of gastrointestinal dysfunction in Japan. The purpose of this study was to analyze the effect of DKT on infants with uncomplicated gastroschisis. Methods: In this retrospective cohort study from 1991 to 2009, we assessed 16 infants with uncomplicated gastroschisis. Eight infants received 0.3 g/kg/day of DKT for 12 months (group 1) and 8 infants did not receive DKT (group 2). We analyzed their body weight as an indicator of the effect of DKT. Results: There were no significant differences in the background characteristics. The body weight of group 1 was significantly increased at the ages of 9 months (p = 0.0348) and 12 months (p = 0.0097), compared with group 2. Multivariate analyses revealed that only DKT administration had a significant impact on body weight gain at the ages of 9 months (p = 0.0201) and 12 months (p = 0.0111). No side effects related to DKT were reported. Conclusion: DKT administration might worksafely and effectively for improvingthe body weight gain in infants with uncomplicated gastroschisis.

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Gastroschisis: the cost of an epidemic

Cited by 55 publications

References 10 publications

Prevalence of gastroschisis and associated hospital time continue to rise in neonates who are admitted for intensive care

Prevalence of gastroschisis and associated hospital time continue to rise in neonates who are admitted for intensive care

Spatial variability of gastroschisis in Canada, 2006–2011: An exploratory analysis

Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis

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