GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation

In-house ammonia induced lung impairment and oxidative stress of ducks

“…Therefore, the level of oxidative stress in the liver may serve as an indirect indicator of the overall oxidative stress status in the organism, including the lungs ( Dasarathy et al, 2017 ). Oxidative stress in lung caused by ammonia may also be one of the causes of pneumonia ( Gauthier et al, 2023 ).…”

Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline

“…The cytotoxic effects on A549, RAW264.7, and THP-1 cells were assessed by performing the Cell Counting Kit-8 (CCK-8) assay following specific protocols (Beyotime, Shanghai, China). When the cells reached 80% to 90% confluence, the medium was discarded, and the cells were washed with PBS three times and cultured in the corresponding serum-free medium ( 48 – 50 ). Doxycycline (0 to 128 μg/mL) in combination with baicalein (2 to 250 μg/mL) was added to 96-well plates along with 1 × 10 4 cells, which were cultured for 24 h at 37°C.…”