2017
DOI: 10.24079/cajms.2017.06.003
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GATA1 Gene Polymorphisms in Down Syndrome Patients

Kherlen Ponkhoon,
Uranchimeg Bayarmagnai,
Sarantuya Jav
et al.

Abstract: Objectives: Down syndrome (DS) patients have a 500 fold higher possibility of developing acute megakaryoblastic leukemia (AMKL), compared with the general population. GATA1 mutations, acquired in the early prenatal stages, contributes to leukemogenesis in AMKL and has been the explanation for the cause of early hematopoietic disorders. The aim of this study was to investigate the influence of GATA1 gene polymorphisms in patients with DS. Methods: Thirty-nine DS patients, aged ≤ 4 years, were recruited into the… Show more

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