GATA3 in Renal Neoplasms: Increased Utility and Potential Pitfalls

Akgul, Mahmut; Sangoi, Ankur R.; Williamson, Sean R.

doi:10.1177/10668969231177883

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…GATA3 and SOX10 are commonly employed markers reliably indicating breast origin; however, they do have limitations [27,28]. It is noteworthy that these markers are not entirely breast-specific, as GATA3 can be expressed in certain renal neoplasms, neuroendocrine neoplasms, and urothelial carcinomas [29,30]. Similarly, SOX10 staining is characteristic of melanocytic tumors and soft tissue neoplasms with neural crest origin [31,32].…”

Section: Discussionmentioning

confidence: 99%

TRPS1 expression in breast angiosarcoma

Pancsa,

Pósfai,

Schubert

et al. 2024

Virchows Arch

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Angiosarcoma (AS) of the breast, a rare mesenchymal neoplasm, exhibits distinct forms based on etiological and genetic features. While cases with typical clinical presentation and morphology allow for a straightforward diagnosis, challenges arise when clinical data are scarce, diagnostic material is limited, or morphological characteristics overlap with other tumors, including undifferentiated carcinomas. The trichorhinophalangeal syndrome protein 1 (TRPS1), once regarded as highly specific for breast carcinomas, now faces doubts regarding its reliability. This study explores TRPS1 expression in breast AS. Our investigation revealed that 60% of AS cases displayed TRPS1 labeling, contrasting with the 40% lacking expression. Scoring by four independent readers established a consensus, designating 12/35 ASs as unequivocally TRPS1-positive. However, uncertainty surrounded nine further cases due to a lack of reader agreement (being substantial as reflected by a kappa value of 0.76). These findings challenge the perceived specificity of TRPS1, shedding light on its presence in a noteworthy proportion of breast ASs. Consequently, the study underscores the importance of a comprehensive approach in evaluating breast ASs and expands the range of entities within the differential diagnosis associated with TRPS1 labeling.

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