GATA3 Inhibits Viral Infection by Promoting MicroRNA-155 Expression

Li, Jiaxin; Haiyilati, Areayi; Zhou, Liyun; Chen, Jun-Cheng; Wang, Yongqiang; Gao, Li; Cao, Hong; Li, Xiaoqi; Zheng, Shijun

doi:10.1128/jvi.01888-21

Cited by 14 publications

(3 citation statements)

References 66 publications

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“…Cellular assays confirmed that MDA5, TBK1, and IRF7 are required for GATA3 expression in poly(I:C) host cells. IBDV induces GATA3 expression via the MDA5-TBK1-IRF7 signaling pathway, inhibiting GATA3-mediated gga-miR-155-5p expression during IBDV replication ( 107 ). TLR3 appears central to regulating disease in patients with DM.…”

Section: Ncrnas Role and Mechanism In Melanoma Differentiation-associ...mentioning

confidence: 99%

Idiopathic inflammatory myopathy and non-coding RNA

Yang,

GuangXuan,

GenMeng

et al. 2023

Front. Immunol.

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Idiopathic inflammatory myopathies (IIMs) are common autoimmune diseases that affect skeletal muscle quality and function. The lack of an early diagnosis and treatment can lead to irreversible muscle damage. Non-coding RNAs (ncRNAs) play an important role in inflammatory transfer, muscle regeneration, differentiation, and regulation of specific antibody levels and pain in IIMs. ncRNAs can be detected in blood and hair; therefore, ncRNAs detection has great potential for diagnosing, preventing, and treating IIMs in conjunction with other methods. However, the specific roles and mechanisms underlying the regulation of IIMs and their subtypes remain unclear. Here, we review the mechanisms by which micro RNAs and long non-coding RNA-messenger RNA networks regulate IIMs to provide a basis for ncRNAs use as diagnostic tools and therapeutic targets for IIMs.

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Section: Ncrnas Role and Mechanism In Melanoma Differentiation-associ...mentioning

confidence: 99%

Idiopathic inflammatory myopathy and non-coding RNA

Yang,

GuangXuan,

GenMeng

et al. 2023

Front. Immunol.

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“…It was found that upon IBDV infection, the expression of GATA-binding protein (GATA) 3 in DF-1 cells markedly increased; this was attributable to the recognition of viral dsRNA by cellular MDA5, subsequently initiating TBK1-IRF7 signaling pathways, thereby promoting GATA3 expression ( Figure 2 ). Phosphorylated GATA3 translocated to the nucleus where it directly bound to the gga-miR-155 promoter, regulating the expression of gga-miR-155 in IBDV-infected or poly (I:C)-treated DF-1 cells [ 130 ]. GATA3 belongs to the GATA-binding protein family, which plays a crucial role in physiological and pathological processes by directly initiating or restricting the transcription of target genes; GATA3, especially, serves as a key transcription factor driving the differentiation of Th2 cells [ 131 , 132 ].…”

Section: Host Response To Ibdv Infection At the Rna Levelmentioning

confidence: 99%

“…Furthermore, our data show that GATA3 inhibited IBDV replication by promoting the expression gga-miR-155, suppressing IBDV replication by enhancing type I IFN expression ( Figure 2 ). These findings indicate that the transcription factor GATA3 plays a critical role in the host antiviral response by promoting gga-miR-155 expression, which deciphers how the expression of a specific miRNA is regulated in host cells with pathogenic infection; moreover, they remarkably further our understanding of the mechanism of the host response against IBDV infection at the RNA level [ 130 ].…”

Section: Host Response To Ibdv Infection At the Rna Levelmentioning

confidence: 99%

Host Combats IBDV Infection at Both Protein and RNA Levels

Zhang

Zheng

2022

Viruses

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Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). In recent years, with the emergence of IBDV variants and recombinant strains, IBDV still threatens the poultry industry worldwide. It seems that the battle between host and IBDV will never end. Thus, it is urgent to develop a more comprehensive and effective strategy for the control of this disease. A better understanding of the mechanisms underlying virus–host interactions would be of help in the development of novel vaccines. Recently, much progress has been made in the understanding of the host response against IBDV infection. If the battle between host and IBDV at the protein level is considered the front line, at the RNA level, it can be taken as a hidden line. The host combats IBDV infection at both the front and hidden lines. Therefore, this review focuses on our current understanding of the host response to IBDV infection at both the protein and RNA levels.

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