This paper critically examines Organic Thin Film Transistors (OTFTs), emphasizing their crucial role in enhancing wearable electronics. Through an in-depth exploration of OTFT fundamental principles and unique characteristics, the paper highlights their advantages, such as unparalleled mechanical flexibility and low-temperature processing capabilities, over traditional semiconductor technologies. It delves into OTFT applications in wearable sensor technologies and healthcare monitoring, illustrating the significant benefits of OTFT integration, including superior energy efficiency and augmented user comfort. Addressing the primary challenges of power consumption, environmental stability, and manufacturing scalability, the study proposes innovative solutions to improve these areas. Central to the research objectives is the enhancement of OTFT performance through strategic material selection, fabrication techniques, and integration approaches to ensure device durability and functionality. The paper concludes with a comprehensive analysis of recent advancements and future directions, underscoring the transformative potential of OTFTs in wearable electronics. This research finds that through interdisciplinary collaboration and innovative engineering, it is possible to mitigate the current limitations of OTFTs, paving the way for their widespread adoption in advanced wearable and healthcare technologies.