Gating ion and fluid transport with chiral solvent

Silva, Savannah A; Singh, Siddharth; Cao, Ethan; Fourkas, John T.; Siwy, Zuzanna S.

doi:10.1039/d3fd00063j

Cited by 3 publications

(1 citation statement)

References 36 publications

(53 reference statements)

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“…Further work by Polster et al and Souna et al described the formation of a lipid-like bilayer of MeCN at a solid silica interface, and the resulting effective surface potential arising as electrolyte ions interact with it. Remarkably, Silva et al reported that this organization of solvent is dependent on chirality, with enantiopure propylene carbonate (PC) exhibiting a lower positive surface potential than racemic PC. In our previous work, we reported the unusual behavior of bare quartz nanopipettes in aprotic solvent as a function of decreasing supporting electrolyte concentration, showing that under specific electrolyte conditions, accumulation of aprotic solvent and the subsequent formation of double-junction diodes within the nanopore gives rise to unexpectedly high rectification ratios .…”

Section: Introductionmentioning

confidence: 99%

The Detection of Trace Metal Contaminants in Organic Products Using Ion Current Rectifying Quartz Nanopipettes

Farrell,

McNeill,

Weiss

et al. 2024

Anal. Chem.

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While ion current rectification (ICR) in aprotic solvent has been fundamentally studied, its application in sensing devices lacks exploration. The development of sensors operable in these solvents is highly beneficial to the chemical industry, where polar aprotic solvents, such as acetonitrile, are widely used. Currently, this industry relies on the use of inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectroscopy (OES) for the detection of metal contamination in organic products. Herein, we present the detection of trace amounts of Pd2+ and Co2+ using ion current rectification, in cyclam-functionalized quartz nanopipettes, with tetraethylammonium tetrafluoroborate (TEATFB) in MeCN as supporting electrolyte. This methodology is employed to determine the concentration of Pd in organic products, before and after purification by Celite filtration and column chromatography, obtaining comparable results to ICP-MS within minutes and without complex sample preparation. Finite element simulations are used to support our experimental findings, which reveal that the formation of double-junction diodes in the nanopore enables trace detection of these metals, with a significant response from baseline even at picomolar concentrations.

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Section: Introductionmentioning

confidence: 99%