Gaucher's disease: Case report of mandibular trauma

Oral Aspects of Gaucher's Disease: A Literature Review and Case Report

“…The main potential surgical complication in GD, especially non‐splenectomized patients, is excessive hemorrhaging caused by thrombocytopenia 15,18,21 . However, in most of the cases reported in the literature, 14,15,18,21‐23 abnormal hemorrhaging was not reported, and healing was normal. In the present case, increased bleeding was indeed noted during extractions but was locally controlled, with no postoperative complications, similar to previous reports.…”

Mandibular and dental manifestations of Gaucher disease

“…This is true in patients with Gaucher disease, as in otherwise healthy individuals, but the existence of Gaucher disease per se is not a reason for curettage or primary extractions. In most cases reported in the literature, postoperative healing was normal without hemorrhagic complications (Weigler et al , 1967; Michanowicz et al , 1967; Bildman et al , 1972; Regenye et al , 1992; Bender and Bender, 1996; Browne, 1977; Horwitz et al , 2007). Nonetheless, prophylaxis against a bleeding diathesis is recommended even in patients on ERT in cases of extractions, dental surgery, or dental prophylaxis that may be extensive.…”

Jaws Features in Type 1 Gaucher Disease

“…Moreover, although Gaucher patients have an increased risk of extragnathic pathologic fractures, an actual pathologic maxillofacial fracture requiring treatment was not reported. 4 Although 3 fracture cases were reported, in the first, a possible fracture was found in a panoramic radiograph, but because no mobility was clinically detected, treatment was not indicated 22 ; the second case was of a Gaucher patient with a mandibular fracture caused by a motor vehicle accident 28 ; and the third was a case of a patient with spontaneous mandibular fractures of an unknown nature, with no data available regarding the diagnosis and treatment of those fractures. 27 Given that jaw involvement in Gaucher is asymptomatic, no treatment is indicated and a follow-up is sufficient.…”

“…Of these, 4 were excluded: 1 case of a post-traumatic mandibular state (not a pathological fracture) with no radiological view of Gaucher disease involving the jaw, 28 1 repeated report 29 of a previously published case, 30 a case series with no jaw radiographs, 25 and a surgical report of osteonecrosis in the maxilla, with no further images of the jaws beyond the lesion. 31 Thus, 10 articles in which 35 Gaucher patients were reported were analyzed.…”