Gaussian Curvature Modulus of an Amphiphilic Monolayer

Templer, Richard H.; Khoo, Bee J.; Seddon, John M.

doi:10.1021/la980701y

Cited by 121 publications

(118 citation statements)

References 38 publications

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“…Also included in Table 6 are data for the Q II 230/G gyroid cubic phase of a monooleoylglycerol/dioleoyl phosphatidylcholine/dioleoyl phosphatidylethanolamine 58:38:4 mol/mol/mol ternary mixture (Templer et al, 1998a). The mean pivotal area and volume, per two chains, are close to the weighted average of these values for the individual components, as demonstrated directly by Templer et al (1998a).…”

Section: Lipid Mixturesmentioning

confidence: 65%

Pivotal surfaces in inverse hexagonal and cubic phases of phospholipids and glycolipids

Marsh

2011

Chemistry and Physics of Lipids

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a b s t r a c tData on the location and dimensions of the pivotal surfaces in inverse hexagonal (H II ) and inverse cubic (Q II ) phases of phospholipids and glycolipids are reviewed. This includes the H II phases of dioleoyl phosphatidylethanolamine, 2:1 mol/mol mixtures of saturated fatty acids with the corresponding diacyl phosphatidylcholine, and glucosyl didodecylglycerol, and also the Q II 230/G gyroid inverse cubic phases of monooleoylglycerol and glucosyl didodecylglycerol. Data from the inverse cubic phases are largely compatible with those from inverse hexagonal H II -phases. The pivotal plane is located in the hydrophobic region, relatively close to the polar-apolar interface. The area per lipid at the pivotal plane is similar in size to lipid cross-sectional areas found in the fluid lamellar phase (L ␣ ) of lipid bilayers.

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Section: Lipid Mixturesmentioning

confidence: 65%

Pivotal surfaces in inverse hexagonal and cubic phases of phospholipids and glycolipids

Marsh

2011

Chemistry and Physics of Lipids

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“…This indicates that a single vesicle is stable for −2 < κ G /κ < 0. [30] For monolayers, the stronger stability criterion −1 < κ G /κ < 0 has been proposed in [31].…”

Section: Materials Parametersmentioning

confidence: 99%

Polymorphism of vesicles with multi-domain patterns

2009

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Vesicle membranes with two coexisting fluid phases can exhibit a variety of domain patterns. These patterns and the associated vesicle shapes are studied theoretically by minimization of energy functionals that depend on the membrane composition and on the material parameters of the membrane. The latter parameters are (i) the bending rigidities and (ii) the Gaussian curvature moduli of the two types of membrane domains as well as (iii) the line tension of the domain boundaries. It is shown that the interplay between these different parameters leads to stable multi-domain patterns with more than two domains for a wide range of membrane composition and material parameters. As the membrane composition or the material parameters are varied, the vesicles can undergo transitions between different patterns of membrane domains. For fixed vesicle volume, an additional domain-induced transition is observed, in which the vesicle shape changes even though the domain pattern does not. The different multi-domain patterns and vesicle shapes are summarized in terms of morphology diagrams.

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“…For the type II lipid amphiphile, dioleoylphosphatidylethanolamine (DOPE), we calculate that the total stored curvature elastic energy for each DOPE molecule in a flat monolayer is approximately 1 k B T (23,25,26). Qualitatively, we can see that the partial submersion of the amphipathic ␣-helical binding domain of CCT into an amphiphilic monolayer allows the release of at least some of this stored curvature elastic energy for type II amphiphiles (Fig.…”

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confidence: 99%