We prove a strong factorization property of interpolation Macdonald polynomials when q tends to 1. As a consequence, we show that Macdonald polynomials have a strong factorization property when q tends to 1, which was posed as an open question in our previous paper with Féray. Furthermore, we introduce multivariate q, t-Kostka numbers and we show that they are polynomials in q, t with integer coefficients by using the strong factorization property of Macdonald polynomials. We conjecture that multivariate q, t-Kostka numbers are in fact polynomials in q, t with nonnegative integer coefficients, which generalizes the celebrated Macdonald's positivity conjecture.