GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies

Wu, Ching‐Yuan; Lin, Yang-Hua; Shu, Li-Hsin; Cheng, Yu‐Ching; Liu, Hung Te

doi:10.1016/j.biopha.2020.110816

Cited by 26 publications

(13 citation statements)

References 40 publications

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“…Peptide nicotinamine from Glycine max, anthraquinone extracted from Rheum officinale, apigenin from Apium graveolus, Delphinidin and Cyanidin from Hibiscus sabdariffa are found effective in ACE2 inhibition [174]. Theaflavin extracted from Camellia sinensis of Assamica variety has been seen to inhibit both protein ACE2 and TMPRSS2 expression at 50µg/ml concentration [176].…”

Section: Natural Compounds: Its Beneficiary Action -Natural Compounds Targeted Against 3clpro Plpro Spike Protein Ace2 Receptormentioning

confidence: 98%

Factors for COVID-19 Infection that Govern the Severity of Illness

Ghosh¹,

Sarkar

Sepay³

et al. 2021

SciMed. J.

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Coronaviruses have been posing a serious threat to mammals and birds and a new class of SARS-CoV is creating havoc to the world after its first incidence in Wuhan City in China in December 2019. These viruses are mainly responsible for causing serious respiratory tract infections which generally appear initially as the common cold and can be lethal just like SARS-CoV. The problems seem to vary and worsen from one person to another depending on age, gender, ethnicity, blood groups, host genetics, and associated comorbidities. Complications should also arise as this virus keeps mutating and evolving. This review points out the various underlying causes behind the severity of the illness and the mechanisms associated with it. This review will help society to understand the risks and severities associated with COVID-19. Individuals with health complexities and predispositions listed in this review are the most vulnerable in terms of severity and should take every possible measure to protect themselves from getting infected. As a consequence, this will lead to a decrease in mortality rates arising from COVID-19. Doi: 10.28991/SciMedJ-2021-0302-9 Full Text: PDF

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Section: Natural Compounds: Its Beneficiary Action -Natural Compounds Targeted Against 3clpro Plpro Spike Protein Ace2 Receptormentioning

confidence: 98%

Factors for COVID-19 Infection that Govern the Severity of Illness

Ghosh¹,

Sarkar

Sepay³

et al. 2021

SciMed. J.

View full text Add to dashboard Cite

show abstract

“…GB-2 , the formula from the Holy Heavenly Mother Peitian Temple in Puzi, Chiayi County, was widely used for the prophylaxis of SARS-CoV-2 infection in Taiwan. It was shown that GB-2 significantly decreased ACE2 protein and mRNA expression in HepG2 and HEK-293T cells in a concentration-dependent (10-250 μg/ml) manner ( C. Y. Wu et al, 2020 ).…”

Section: Phytochemicals and Naturally Occurring Substances And Ace2mentioning

confidence: 99%

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

Öz

Lorke

Kabbani

2021

Pharmacology & Therapeutics

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The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, employs angiotensin converting enzyme 2 (ACE2) as its primary target for cell surface attachment and likely entry into the host cell. Thus, understanding factors that may regulate the expression and function of ACE2 in the healthy and diseased body is critical for clinical intervention. Over 66% of all adults in the United States are currently using a prescription drug and while earlier findings have focused on possible upregulation of ACE2 expression through the use of renin angiotensin system (RAS) inhibitors, mounting evidence suggests that various other widely administered drugs used in the treatment of hypertension, heart failure, diabetes mellitus, hyperlipidemias, coagulation disorders, and pulmonary disease may also present a varied risk for COVID-19. Specifically, we summarize mechanisms on how heparin, statins, steroids and phytochemicals, besides their established therapeutic effects, may also interfere with SARS-CoV-2 viral entry into cells. We also describe evidence on the effect of several vitamins, phytochemicals, and naturally occurring compounds on ACE2 expression and activity in various tissues and disease models. This comprehensive review aims to provide a timely compendium on the potential impact of commonly prescribed drugs and pharmacologically active compounds on COVID-19 pathology and risk through regulation of ACE2 and RAS signaling.

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“…Inhibition of TMPRSS2 by a triterpenoid named platycodin D present in Platycodon grandiflorum (Kim et al 2021b ), theaflavin from camellia sinensis var. assamica (Wu et al 2020b ), and tannic acid (Wang et al 2020b ) are limited natural examples being examined by in vitro screening assays. Diethyl ether fraction of Aframomum melegueta with IC 50 of 0.03 mg/L is the only natural extract being in vitro validated for furin inhibition (Omotuyi et al 2021 ).…”

Section: Natural Based Therapeutics For Inhibition Of Sars-cov-2 Infe...mentioning

confidence: 99%

Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms

et al. 2022

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In addition to the typical respiratory manifestations, various disorders including involvement of the nerve system have been detected in COVID-19 ranging from 22 to 36%. Although growing records are focusing on neurological aspects of COVID-19, the pathophysiological mechanisms and related therapeutic methods remain obscure. Considering the increased concerns of SARS-CoV-2 potential for more serious neuroinvasion conditions, the present review attempts to focus on the neuroprotective effects of natural compounds as the principle source of therapeutics inhibiting multiple steps of the SARS-CoV-2 infection cycle. The great majority of the natural products with anti-SARS-CoV-2 activity mainly inhibit the attachment, entry and gene expression rather than the replication, assembly, or release. Although microbial-derived natural products comprise 38.5% of the known natural products with neuroprotective effects following viral infection, the neuroprotective potential of the majority of microorganisms is still undiscovered. Among natural products, chrysin, huperzine A, ginsenoside Rg1, pterostilbene, and terrein have shown potent in vitro neuroprotective activity and can be promising for new or repurpose drugs for neurological complications of SARS-CoV-2.

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GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies

Abstract: Graphical abstract

Cited by 26 publications

References 40 publications

Factors for COVID-19 Infection that Govern the Severity of Illness

Factors for COVID-19 Infection that Govern the Severity of Illness

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms

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