1997
DOI: 10.1053/gast.1997.v113.pm9247478
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GB virus C RNA in serum, liver, and peripheral blood mononuclear cells from patients with chronic hepatitis B, C, and D

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Cited by 59 publications
(54 citation statements)
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“…[4][5][6] One should also be aware that there are many sites in the liver apart from the hepatocytes in which replication of GBV-C could occur, as in endothelial cells, cholangiocytes, Kupffer cells, or lymphocytes, and the dynamics of GBV-C infection in these structures may be quite different from those in hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
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“…[4][5][6] One should also be aware that there are many sites in the liver apart from the hepatocytes in which replication of GBV-C could occur, as in endothelial cells, cholangiocytes, Kupffer cells, or lymphocytes, and the dynamics of GBV-C infection in these structures may be quite different from those in hepatocytes.…”
Section: Discussionmentioning
confidence: 99%
“…[1][2][3] The three studies dealing with the detection of replicative intermediates (minus-stranded RNA) of GBV-C in the liver, a phenomenon that can be taken in favor of replication in the liver, have revealed contradictory results. [4][5][6] Thus, Madejó n et al detected plus-stranded (genomic) GBV-C RNA in serum, liver, and peripheral blood mononuclear cells, but minus-stranded (antigenomic) GBV-C RNA was found only in the liver and was not present in the serum or peripheral blood mononuclear cells. 4 The authors therefore concluded that GBV-C replicates in the liver.…”
mentioning
confidence: 99%
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“…In a recent study from Madejon et al, both genomic and antigenomic strands of GBV-C RNA were identified in liver. 17 If true, this information would suggest that HGV replication is occurring in the liver but at a very low rate. However, given the methodological problems in quantitating accurately the negative strand of GBV-C/HGV, confirmation of these results must be awaited before concluding that HGV is an hepatropic virus.…”
Section: Discussionmentioning
confidence: 99%
“…Since the majority of HGV/ GBV-C positive patients with HCC are also found to be coinfected with either HBV or HCV, it is difficult to assess the true role of HGV in the etiology of HCC [56] . Nevertheless, results from a number of studies clearly indicate a primary lymphotropic nature of GBV-C/HGV as the viral replicative forms (an indicator of active GBV-C/HGV replication) have been detected in circulating lymphocytes, bone marrow, spleen, mononuclear cells and lymph nodes in a proportion of GBV-C/HGV infected patients [57,[59][60][61][62][63] . Considering the similarity between HCV and HGV/ GBV-C a similar relationship to the development of lymphoma has been expected [64] .…”
Section: Hgv/gbv-c and Nhlmentioning
confidence: 99%