GC‐MS Analysis: <i>In Vivo</i> Hepatoprotective and Antioxidant Activities of the Essential Oil of <i>Achillea biebersteinii</i> Afan. Growing in Saudi Arabia

Alsaid, Mansour S.; Mothana, Ramzi A.; Al-Yahya, Mohammed A.; Rafatullah, Syed; Al-Sohaibani, Mohammed; Khaled, Jamal M.; Alatar, Abdulrahman A.; Alharbi, Naiyf S.; Kürkçüoğlu, Mine; Baser, Hüsnü Can

doi:10.1155/2016/1867048

Cited by 22 publications

(18 citation statements)

References 28 publications

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“…Chemical profile of the EOs studied herein was similar to previous reports concerning the test species belonging to the Saudi flora or similar biota. For example, a- terpinene (29.2%) and P -Cymene (22.9%) were abundant in A. biebersteinii EO growing wild in the southern region of Saudi Arabia ( Al-Said et al., 2016 ). Whereas, ascaridol, camphor and p -Cymene are reported as the major fractions in the Egyptian and Jordanian A. biebersteinii oil ( Bader et al., 2003 ; Nenaah, 2014a , b ).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition, insecticidal and biochemical effects of two plant oils and their major fractions against Aedes aegypti, the common vector of dengue fever

Almadiy

2020

Heliyon

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In an attempt to reduce the massive application of the toxic chemical pesticides, essential oils (EOs) of Achillea biebersteinii and Juniperus procera were obtained through hydrodistillation and analyzed using (GC–FID) and (GC–MS). α-terpinene and p -cymene were detected as the major components in the EO of A. biebersteinii , while eugenol and ß -caryophyllene were the major constituents in the EO of J. procera . The plant EOs and major fractions act as considerable mosquitocides against Aedes aegypti L, the common transmitter of Dengue fever. The EOs and major fractions were tested at 6.25, 12.5, 25, 50 and 100 μl/l. Insect mortality was time and dose-dependent, and the adult stage was more sensitive than larvae. At a concentration of 50 μl/l, 24 post treatment larval and adult mortality ranged between (40.3 and 89.3%) and (51.4 and 95.6%), respectively. The LC 50 values ranged between 12.2 and 70.1 μl/l against larvae and between 10.1 and 63.12 μl/l against adults. All of the crude EOs were more potent than their major fractions. Eugenol and ß -caryophyllene showed strong mosquitocidal activity than p -cymene and α-terpinene. The corrected percentage mortality was increased over time with all of the test materials. In terms of lethal time required to kill 50% of the population (LT 50 ), a concentration of 100 μl/l of J. procera EO showed LT 50 values of 2.3 and 1.7 h against larvae and adult, respectively. The EOs induced considerable inhibition of acetylcholinesterase activity, where J. procera crude oil (IC 50 = 13.12mM) and eugenol (IC 50 = 19.65mM) were the most potent. Results proved that the test plant oils and their major fractions could be developed as natural pest control agents to control A. aegypti .

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Section: Discussionmentioning

confidence: 99%

Chemical composition, insecticidal and biochemical effects of two plant oils and their major fractions against Aedes aegypti, the common vector of dengue fever

Almadiy

2020

Heliyon

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“…The results showed that the administration of the essential oils at a dose of 0,2 mL/ kg has a significant hepatoprotective activity against CCl 4 induced liver damage compared with control. Furthermore, the biochemical assay indicated that this oil contains: 56.3% of the monoterpene hydrocarbons, 29.2% of the monoterpene hydrocarbons alfa-terpinene, 22.9% p-cymene, 4.7% terpinen-4-ol, 4.3% of 1,8cineole, 3.9% of trans-p-menth-2-en-1ol, 3.1% of the ascaridole, 2.5% of transpiperitone oxide and 2.1% carvacrol [7].…”

Section: Methodsmentioning

confidence: 99%

Hepatoprotective Essential Oils: A Review

Daoudi

Bnouham

2020

J Pharmacopuncture

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Objectives: Several toxins and molecules are able to damage the liver, causing the hepato-toxicity. This disorder can be protected naturally, by some essential oils obtained from different plants. In this review we are cited some of these compounds that have been tested by their hepatoprotective effect. Methods: We reviewed 83 articles published between 1981 and 2018 in English via three databases Sciencedirect, Springer and PubMed. So, we have used the keywords: Hepatoprotective effect, liver disease, plants and essential oils. Results and conclusion: In this work, we classified the plants; contain the essential oils, in alphabetical order as a table containing the scientific, family names, information plants, the experimental assay and the results obtained from the hepatoprotective studies. We have described 27 species belonging to 12 families: Lamiaceae (7 species), Asteraceae (6 species), Umbellifereae (3 species), Apiaceae (3 species) are the main families which enclose the species that was studied. The study also includes the major compounds isolated from some of these essential oils. The most of those compounds belong to terpene class essentially cineol, carvacrol and thymol. Thus, the different essential oils that have been cited in this review were shown that have an antioxidant activity.

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“…Retention indices ( RI s) were calculated for each compound against n ‐alkane standards (C 6 – C 40 ) according to the Kovats method. The constituents of essential oils were identified by comparing with the NIST Chemistry web book and literature published …”

Section: Methodsmentioning

confidence: 99%

Variation on Composition and Bioactivity of Essential Oils of Four Common Curcuma Herbs

Zhang

Yang

Chen

et al. 2017

Chemistry & Biodiversity

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Chemical compositions, antioxidative, antimicrobial, anti-inflammatory, and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin, and Curcuma kwangsiensis) rhizomes in P. R. China are comparatively studied. In total, 47, 49, 35, and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin, and C. kwangsiensis essential oils by GC/MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36.47%), respectively. Moreover, C. kwangsiensis essential oils display the strongest DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity (IC , 3.47 μg/ml), much higher than ascorbic acid (6.50 μg/ml). C. phaeocaulis oils show the best antibacterial activities against Escherichia coli (MIC, 235.54 μg/ml), Pseudomonas aeruginosa (391.31 μg/ml) and Staphylococcus aureus (378.36 μg/ml), while C. wenyujin and C. kwangsiensis oils show optimum activities against Candida albicans (208.61 μg/ml) and Saccharomyces cerevisiae (193.27 μg/ml), respectively. C. phaeocaulis (IC , 4.63 μg/ml) and C. longa essential oils (73.05 μg/ml) have the best cytotoxicity against LNCaP and HepG2, respectively. C. kwangsiensis oils also exhibit the strongest anti-inflammatory activities by remarkably down-regulating expression of COX-2 and TNF-α. Therefore, due to their different chemical compositions and bioactivities, traditional Chinese Curcuma herbs should be differentially served as natural additives for food, pharmaceutical, and cosmetic.

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GC‐MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia

Cited by 22 publications

References 28 publications

Chemical composition, insecticidal and biochemical effects of two plant oils and their major fractions against Aedes aegypti, the common vector of dengue fever

Chemical composition, insecticidal and biochemical effects of two plant oils and their major fractions against Aedes aegypti, the common vector of dengue fever

Hepatoprotective Essential Oils: A Review

Variation on Composition and Bioactivity of Essential Oils of Four Common Curcuma Herbs

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