GC-MS Analysis of the Active Compound in Ethanol Extracts of White Pepper (Piper nigrum L.) and Pharmacological Effects

Arsana, I Nyoman; Juliasih, Ni; Widyantari, A Ayu Sauca Sunia; Suriani, Ni; Manto, Agus

doi:10.55705/cmbr.2022.351720.1051

Cited by 11 publications

(4 citation statements)

References 34 publications

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“…Recently, several studies have focused on the effect of different plant extracts on the function of different human body systems and healthy complexion (29)(30)(31)(32). Momordica charantia fruit contains flavonoid components that can regulate cholesterol and lipoproteins levels (33).…”

Section: Discussionmentioning

confidence: 99%

Synergic Effects of Rosemary Extract and Aerobic Exercise on Sperm Parameters and Testicular Tissue in an Aged Rat Model

et al. 2023

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Background: Aging, which has globally increased, reduces male fertility and damages the testes. The effect of aerobic exercises and the use of medicinal plants like rosemary on fertility remains controversial. Objectives: The aim of this study was to evaluate the effects of rosemary extract and exercise on testicular tissue. Methods: In this study, 30 male Wistar rats were divided into five groups: (1) Control group (without treatment); (2) Gavage group [received the solvent of rosemary extract (distilled water) and put on a turned-off treadmill for 10 minutes daily]; (3) Exercise group (put on a turned-on treadmill based on an exercise protocol for 12 weeks); (4) Extract group (received 100 mg/kg of rosemary extract for 12 weeks); (5) Exercise and extract group (received 100 mg/kg of rosemary extract and concurrently put on a turned-on treadmill for 12 weeks). After the treatment, the testis tissue of rats was collected, and the seminiferous tubular diameter, luminal diameter, and epithelial height were analyzed. Also, spermatogenic lineage was counted in different groups. Results: The tubal diameter and epithelial height significantly increased following the consumption of rosemary extract and exercise training compared with the control group (P < 0.01). Also, a significant increase was observed in the luminal diameter in the exercise group compared to the control group (P < 0.01). The rosemary extract and exercise training significantly increased the number of spermatogonia cells (P < 0.01). However, there were no significant differences in the number of primary spermatocyte and spermatozoa cells among the different groups (P > 0.05). Conclusions: Generally, low-intensity aerobic exercise improved testicular histomorphology parameters. However, rosemary extract had no positive effects as an aerobic exercise on male fertility during aging.

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Section: Discussionmentioning

confidence: 99%

Synergic Effects of Rosemary Extract and Aerobic Exercise on Sperm Parameters and Testicular Tissue in an Aged Rat Model

et al. 2023

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“…The work of Ojo et al ( 2021) showed a great antibacterial power of purified piperine on S. aureus and E. coli and S. enterica. However, the work done by Arsana et al (2022) showed that white P. nigrum would also contain Piperine. This difference observed in the antimicrobial activity could be explained by the difference in the composition of the different P. nigrum tested.…”

Section: Discussionmentioning

confidence: 99%

Effect of Piper nigrum, Thymus vulgaris and Syzigiuim aromaticum essential oils on the microbiological and sensory quality of Pork sausages during preservation

TCHIKOUA¹,

FOGANG²,

SADO³

et al. 2023

Afr. J. Microbiol. Res.

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The use of essentials oils (EOs) as alternative of nitrites and nitrates in sausages will be proposed in this study. For this purpose, the minimal inhibitory concentration (MIC) of white Piper nigrum of Penja, Thymus vulgaris and Syzigiuim aromaticum EOs were determined in vitro against Escherichia coli ATCC25922, Salmonella enteritidis 155A and Staphylococcus aureus NCTC10652. It follows from this study that, T. vulgaris EO was active on E. coli ATCC25922, S. aureus NCTC10652 and S. enteritidis 155A with MICs of 312.5, 625 and 1250 ppm, respectively. As for S. aromaticum EO, it reduced the same germs with MICs of 1250, 2500 and 5000 ppm, respectively. The combination of MICs of 1250 (T. vulgaris) and 5000 ppm (S. aromaticum) was selected (CMICR) for its bactericidal effect on 03 pathogens. The CMICR totally reduced E. coli ATCC25922 and S. enteritidis 155A after 3 days of storage. The sensory analysis shows that SAUS 324 and SAUS 589 produced with white P. nigrum of Penja were appreciated by the panelists. The combination of CMICR and white P. nigrum of Penja can be considered as an alternative to chemical preservatives to limit the growth of bacteria and improve the sensory characteristics of sausages.

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“…Plant phytochemicals are the first line of treatment for all types of human cancers in traditional medicine. Some studies have shown that medicinal plants and their isolated compounds suppress the expression of certain genes and specific biosynthetic pathways involved in cancer development (35)(36)(37). Anticancer activity of ethanol extracts of roots and aerial parts of nine ethnopharmacological medicinal plants of Golestan province (Iran), in terms of their cytotoxicity against L-929, AGS, HT-29, and esophageal adenocarcinoma cells, through promoting apoptosis and immunomodulatory effects.…”

Section: Discussionmentioning

confidence: 99%

Finding Molecular Inhibitors of the Inflammatory Pathway in the Large Intestine Along with Molecular Dynamics with Emphasis on the Use of TCM Database

Sargazi,

Fakheri,

Bahari

et al. 2023

Gene Cell Tissue

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Background: Due to the fact that colon inflammation is one of the most common diseases in the country, the interest in using herbal medicines to cure intestinal inflammation is increasing day by day. Objectives: In the present research, we aimed to identify the target molecules in the immune system by analyzing the transcriptome of these diseases and using the virtual screening technique to search for plant compounds that have antagonistic capabilities for these receptors. Also, by using this in vitro culture, check and confirm the anti-inflammatory properties of these compounds. Methods: The population study includes 200 human transcriptome runs, about 60 thousand compounds related to medicinal plants, and in vitro experiments with at least three experimental replicates and three technical replicates. In this study, the anticancer and immunomodulatory effects of aqueous extracts of rosemary and nettle medicinal plants were investigated as a promising source of cancer treatment against the AGS cell line derived from gastric cancer (AGS-Cell-DGC). IC50 of the extracts was determined by MTT assay. Flow cytometry and real-time PCR (RT-PCR) were measured. Results: The MTT test on the survival percentage of AGS cell line (90%) derived from gastric cancer showed that the highest amount of live cells was observed in control, and the lowest amount was observed in the simultaneous combination of rosemary and nettle extract and then nettle (100%). The highest expression of interleukin 1-beta (IL-1β) gene occurred in the control, and the lowest expression occurred in the simultaneous combination of nettle and rosemary extracts. The highest expression of tumor necrosis factor-alpha (TNF-α) gene occurred in the control, and the lowest expression occurred in the simultaneous combination of nettle and rosemary extracts. Conclusions: The results showed that the highest amount of live cells was observed in the control, and the lowest amount was observed in the simultaneous combination of rosemary and nettle extract and then nettle (100%) alone. However, further clinical trials are needed to confirm the results of this research.

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GC-MS Analysis of the Active Compound in Ethanol Extracts of White Pepper (Piper nigrum L.) and Pharmacological Effects

Cited by 11 publications

References 34 publications

Synergic Effects of Rosemary Extract and Aerobic Exercise on Sperm Parameters and Testicular Tissue in an Aged Rat Model

Synergic Effects of Rosemary Extract and Aerobic Exercise on Sperm Parameters and Testicular Tissue in an Aged Rat Model

Effect of Piper nigrum, Thymus vulgaris and Syzigiuim aromaticum essential oils on the microbiological and sensory quality of Pork sausages during preservation

Finding Molecular Inhibitors of the Inflammatory Pathway in the Large Intestine Along with Molecular Dynamics with Emphasis on the Use of TCM Database

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