GC-MS analysis of the composition of serum IgG glycans as a potential diagnostic marker of advanced endometriosis – Preliminary report

Sołkiewicz, Katarzyna; Krotkiewski, Hubert; Jędryka, Marcin; Jakubiak-Augustyn, Anna; Kratz, Ewa Maria

doi:10.1016/j.cca.2023.117489

Clinica Chimica Acta

2023

DOI: 10.1016/j.cca.2023.117489

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GC-MS analysis of the composition of serum IgG glycans as a potential diagnostic marker of advanced endometriosis – Preliminary report

Katarzyna Sołkiewicz

Hubert Krotkiewski

Marcin Jędryka

et al.

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2024

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Cited by 3 publications

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Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives

Tang,

Lin,

et al. 2024

Reprod Medicine & Biology

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BackgroundEndometriosis is a common gynecological disease affecting women of reproductive age. Patients with endometriosis frequently experience severe chronic pain and have higher chances to experience infertility. Progesterone resistance is a major problem that develops during the medical treatment of endometriosis, which often leads to treatment failure of hormonal therapies. Previous studies indicated that the dysregulation of progesterone receptors (PR) is the primary factor leading to progesterone resistance in endometriosis.MethodsThis review article systematically reviewed and summarized findings extracted from previously published papers available on PubMed, encompassing both experimental studies and clinical trials.Main findingsVarious determinants influencing PR expression in endometriosis have been identified, including the environmental toxins, microRNAs, cell signaling pathways, genetic mutations, and the pro‐inflammatory cytokines. The selective estrogen/progesterone receptor modulators have emerged as novel therapeutic approaches for treating endometriosis, offering potential improvements in overcoming progesterone resistance.ConclusionConcerns and limitations persist despite the newly developed drugs. Therefore, studies on unraveling new therapeutic targets based on the molecular mechanisms of progesterone resistance is warranted for the development potential alternatives to overcome hormonal treatment failure in endometriosis.

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Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives

Tang,

Lin,

et al. 2024

Reprod Medicine & Biology

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Impact of glycosylation on viral vaccines

Lembo,

Molinaro,

De Castro

et al. 2024

Carbohydrate Polymers

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The Degree of Branching of Serum IgG N-glycans as a Marker of Advanced Endometriosis

Kratz,

Sołkiewicz,

Jędryka

2024

Molecules

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Endometriosis is a gynecological disease for which the diagnostics are difficult and often invasive; therefore, non-invasive diagnostic methods using sensitive and specific parameters present in easily available body fluid such as blood serum are needed for the detection of this disease. Our study aimed to answer the question of whether there are any differences between women with advanced endometriosis (AE), patients with gynecological diseases other than endometriosis (NE), and healthy women (control) in terms of the number of antennas of N-glycans from serum IgG. The degree of branching of IgG N-glycans was determined by a modified lectin ELISA with biotinylated lectin Con A (Canavalia ensiformis agglutinin) recognizing α-linked mannose, specifically reacting with biantennary N-glycans. The PHA-L/Con A ratio was calculated from the obtained N-glycan reactivities with Con A and PHA-L (Phaseolus vulgaris leucoagglutinin, specific to tri- and/or tetra-antennary N-linked glycans). The expression of Con A-reactive biantennary N-glycans in serum IgG was significantly lower in the control group than in the NE group (p = 0.045). The values of the PHA-L/Con A ratio were significantly higher in the NE group than in the AE and control groups (p = 0.019 and p = 0.022, respectively). The PHA-L/Con A ratio could be taken into account as a parameter helpful in the non-invasive diagnosis of advanced endometriosis, thus differentiating this disease from other gynecological diseases with an inflammatory background.

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GC-MS analysis of the composition of serum IgG glycans as a potential diagnostic marker of advanced endometriosis – Preliminary report

Cited by 3 publications

References 22 publications

Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives

Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives

Impact of glycosylation on viral vaccines

The Degree of Branching of Serum IgG N-glycans as a Marker of Advanced Endometriosis

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