GC-MS analysis, pH and antioxidant effect of Ruzu herbal bitters on alloxan-induced diabetic rats

Obasi, David C.; Ogugua, Victor N.

doi:10.1016/j.bbrep.2021.101057

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…SOD is an important enzyme that scavenges superoxide radical (O 2•− ) to H 2 O 2 and molecular oxygen, 47 while CAT and GPx are involved in the conversion of H 2 O 2 to H 2 O, without which the generated H 2 O 2 will destroy membrane lipids, releasing large amounts of MDA as a byproduct of lipid peroxidation. 48 There are contrasting reports in the literature on the concentrations of antioxidants in circulation in the diabetic state. Whereas some studies that evaluated the antioxidant status and SOD activity in patients with diabetes compared with healthy controls found no significant differences between controls and diabetic groups in terms of SOD activity, 49 some other studies reported decreased serum activities of SOD and catalase in diabetic rats.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Previous studies reported that increased levels of free radicals in diabetes may increase the activities of antioxidant enzymes that are activated to abrogate them. 48,52 Therefore, higher SOD, GPx, CAT, GSH, and MDA concentrations in the sera of the diabetic group are an indication of oxidative stress in the diabetic group.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Antioxidant enzymes like SOD, CAT, and GPx have been shown to be vital in eliminating reactive oxygen species. SOD is an important enzyme that scavenges superoxide radical (O 2•– ) to H 2 O 2 and molecular oxygen, while CAT and GPx are involved in the conversion of H 2 O 2 to H 2 O, without which the generated H 2 O 2 will destroy membrane lipids, releasing large amounts of MDA as a byproduct of lipid peroxidation …”

Section: Discussionmentioning

confidence: 99%

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Effect of Different Doses of Unripe Plantain (Musa paradisiaca) or Their Combinations with Ginger (Zingiber officinale) on Some Biochemical Parameters, and Hepatic and Pancreatic Histology of Streptozotocin-Induced Diabetic Rats

Iroaganachi,

Edem,

Akpan

et al. 2023

ACS Food Sci. Technol.

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The effect of different doses of unripe plantain or their combinations with ginger (25 g/kg) on some parameters in streptozotocin (STZ)-induced diabetic rats was studied. Following diabetes induction, 45 male albino rats were divided into nine groups of five rats each: groups 1 and 2 (control and diabetic) received rat pellets, group 3 received 200 g/kg unripe plantain-incorporated feed (UPIF), group 4 received 400 g/kg UPIF, group 5 received 600 g/kg UPIF, group 6 received 200 g/kg unripe plantain + 25 g/kg ginger-incorporated feed (GIF), group 7 received 400 g/kg unripe plantain +25 g/kg GIF, group 8 received 600 g/kg unripe plantain +25 g/kg GIF, and group 9 was treated with glibenclamide (2.5 mg/kg). STZ administration induced hyperglycemia, systemic oxidative stress, and inflammation and also altered the liver and pancreas histology of the rats, which was mitigated by unripe plantain (400 g/kg) and ginger (25 g/kg) diet compared with other treatments.

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Section: ■ Resultsmentioning

confidence: 99%

Section: ■ Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Different Doses of Unripe Plantain (Musa paradisiaca) or Their Combinations with Ginger (Zingiber officinale) on Some Biochemical Parameters, and Hepatic and Pancreatic Histology of Streptozotocin-Induced Diabetic Rats

Iroaganachi,

Edem,

Akpan

et al. 2023

ACS Food Sci. Technol.

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“…Combining the results of the regression coefficients plot of IC50 values of DPPH and ABTS, 9 peaks (peaks 1, 2, 3, 4, 6, 7, 8, 10, and 13) were identified and these peaks were positively correlated with the antioxidant effect of SEO. Previous studies reported that Ylangene (peak 4) (Liu et al 2021a ), α-Muurolene (peak 7) (Mennai et al 2021 ), and β-Bisabolene (peak 10) (Obasi and Ogugua 2021 ) were showed promising antioxidant activity. The spectrum-effect relationship analysis results suggested that these components might be positively correlated with the antidepressant-like effect of SEO.…”

Section: Discussionmentioning

confidence: 99%

Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation

et al. 2022

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The present study aimed to evaluate the antidepressant-like effect of essential oils from Schisandra chinensis (Turcz.) Baill. (SEO) and its possible mechanisms of SEO. The behavioral despair mouse model in vivo and H 2 O 2 -induced PC12 cells model in vitro were employed. And the potential effective components were identified by the spectrum-effect relationships analysis. SEO significantly decreased the immobility time in the forced swimming test and tail suspension test, which indicated a promising antidepressant-like effect of SEO in depressed mice. The decreased levels of SOD, GSH, and CAT, and increased levels of MDA were significantly reversed by SEO treatment, which showed good antioxidant activities both in vitro and in vivo. Besides, SEO significantly promoted the nuclear translocation of Nrf2 and the expression of HO-1 in depressed mice and H 2 O 2 -induced PC12 cells. The histopathological examination results showed a potential neuronal protective effect of SEO in the hippocampus and cortex. Furthermore, the upregulation of PI3K/AKT/GSK3β signaling was observed after SEO treatment in the H 2 O 2 -induced PC12 cells. Additionally, based on the spectrum-effect relationship analysis, 9 peaks were identified as positively correlated with the antioxidant activity of SEO. These results suggested that SEO promoted Nrf2/HO-1 pathway to improve the oxidative stress status and exerted the antidepressant-like effects.

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“…The variance in study design may explain the differences in CRP levels in diabetic animals. Although alloxan induces diabetes through a different mechanism (oxidative stress through Fenton reaction) than streptozotocin (alkylation of DNA) [ 152 ], higher doses of alloxan applied to male and female rats induce the same effects on diabetes development and alterations of CRP levels in circulation, as streptozotocin [ 150 , 153 , 154 ]. Some authors suggest that infections in T2DM should be treated with antibiotics and indicate that medication with fluoroquinolone antibiotics may decrease elevated CRP values in diabetic rats [ 155 ].…”

Section: T2dm and Crpmentioning

confidence: 99%

Role of C-Reactive Protein in Diabetic Inflammation

Stanimirović

Radovanović

Banjac

et al. 2022

Mediators of Inflammation

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Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation is a triggering factor in the origin of T2DM. Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which are pivotal factors for CRP stimulation. Furthermore, it is known that hepatocytes produce relatively low rates of CRP in physiological conditions compared to T2DM patients, in which elevated levels of inflammatory markers are reported, including CRP. CRP also participates in endothelial dysfunction, the production of vasodilators, and vascular remodeling, and increased CRP level is closely associated with vascular system pathology and metabolic syndrome. In addition, insulin-based therapies may alter CRP levels in T2DM. Therefore, determining and clarifying the underlying CRP mechanism of T2DM is imperative for novel preventive and diagnostic procedures. Overall, CRP is one of the possible targets for T2DM progression and understanding the connection between insulin and inflammation may be helpful in clinical treatment and prevention approaches.

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GC-MS analysis, pH and antioxidant effect of Ruzu herbal bitters on alloxan-induced diabetic rats

Cited by 7 publications

References 34 publications

Effect of Different Doses of Unripe Plantain (Musa paradisiaca) or Their Combinations with Ginger (Zingiber officinale) on Some Biochemical Parameters, and Hepatic and Pancreatic Histology of Streptozotocin-Induced Diabetic Rats

Effect of Different Doses of Unripe Plantain (Musa paradisiaca) or Their Combinations with Ginger (Zingiber officinale) on Some Biochemical Parameters, and Hepatic and Pancreatic Histology of Streptozotocin-Induced Diabetic Rats

Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation

Role of C-Reactive Protein in Diabetic Inflammation

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