GC-MS Determination of Kava-Pyrones inAlpinia zerumbet Leaves

Kuster, Ricardo Machado; Mpalantinos, M. A.; Holanda, Maria C. de; Lima, Paula Feliciano de; Brand, Elimar T.; Parente, José Paz

doi:10.1002/(sici)1521-4168(19990201)22:2<129::aid-jhrc129>3.0.co;2-r

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…Kavalactones Eighteen kavalactones (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), which were identified from kava roots, have already been covered in the review by Bilia et al, [8] namely 11-hydroxy-12-methoxydihydrokavain (1), 7,8dihydrokavain (2), dihydromethysticin (3), 5,6,7, 8-tetrahydroyangonin (4), 11,12-dimethoxy-5,6-dihydrokavain (5), 7,8-dihydro-5-hydroxykavain (6), kavain (7), methysticin (8), 5,6-dihydroyangonin (9), hydroxykavain (10), 5,6-dehydromethysticin (11), 7,8-dihydroyangonin (12), desmethoxyyangonin (13), yangonin (14), 11-methoxyangonin (15), 10-methoxyangonin (16), 11-hydroxyangonin (17), and 11-methoxy-12-hydroxydehydrokavain (18). Among these kavalactones, compounds 2, 3, 7, 8, 13, 14 are the most abundant in the roots of P. methysticum.…”

Section: Kavalactones Isolated From Plantsmentioning

confidence: 99%

“…[10][11][12] Chromatographic separation of the methylene chloride extract of P. methysticum roots yielded a new kavalactone 11-methoxy-5,6-dihydroyangonin (19). [13] Dihydro-5,6-dehydrokavain (DDK, 20), a main constituent in the leaves of Alpinia zerumbet, was determined using GC-MS by Kuster et al [14] Six kavalactones, 4-methoxy-6-(11,12-methylenedioxydihydrostyryl)-2-pyrone (21), 4-methoxy-6-(11,12-methylenedioxy-14-methoxy-dihydrostyryl)-2-pyrone (22), 4-methoxy-6(11,-12-methylenedioxy-10,14-dimethoxydihydrostyryl)-2-pyrone (23), 4-methoxy-6-(11,12-methylenedioxy-14-methoxystyryl)-2pyrone (24), 4-methoxy-6-(11,12-methylenedioxystyryl)-2pyrone (25), and 4-methoxy-6-(11,12-dimethylstyryl)-2-pyrone (26) were isolated from the EtOAc-soluble fraction of the aqueous EtOH (1:4) extract of Polygala sabulosa (Polygalaceae). [15] Matsuda et al isolated 7,8-epoxyyangonin (27) from the extract of the roots of P. methysticum.…”

Section: Kavalactones Isolated From Plantsmentioning

confidence: 99%

See 1 more Smart Citation

Plant-Derived Kavalactones and Their Bioactivities

Zhang¹,

Wu²,

Liu³

et al. 2018

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Kavalactones, mainly found in Piper methysticum, are a class of lactone compounds usually with an arylethylene-pyrone skeleton. Till now, fifty-one kavalactones have been isolated from the genera Piper, Alpinia, Amomum, Polygala, Goniothalamus, and Dumortiera. The bioactivities of six kavalactones, kawain, 7,8-dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyagonin, have been studied extensively. This review aims to give an overview of kavalactones in the plants and their various bioactivities.

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Section: Kavalactones Isolated From Plantsmentioning

confidence: 99%

Section: Kavalactones Isolated From Plantsmentioning

confidence: 99%

Plant-Derived Kavalactones and Their Bioactivities

Zhang¹,

Wu²,

Liu³

et al. 2018

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“…Tannins are cited as very commonly occurring substances in all Zingiberaceae species (Tomlinson, 1969); however, they have been understudied in the genus Alpinia. The leaves and roots of A. zerumbet contain kavain (4) and dehydro-kavain (Kuster et al, 1999); kavalactones act on the central f.: found; n.f. : not found nervous system and give this plant the same anxiolytic and sedative properties of the plant popularly known as "kava-kava" (Piper methysticum) (Cass, 2004).…”

Section: Phytochemical Studiesmentioning

confidence: 99%

Therapeutic value of the genus Alpinia, Zingiberaceae

Victório¹

2011

Rev. bras. farmacogn.

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Plants containing bioactive substances have increasingly become the object of research studies, particularly those plants with therapeutic value. Many species of the genus Alpinia provide a variety of medicinal properties, such as, Alpinia zerumbet (Pers.) Burtt et Smith and A. purpurata (Vieill) K. Schum, which have a significant presence in Brazil. These species have been commercialized in the food and cosmetic industries. However, their greatest importance arises from the medicinal properties of their essential oils containing flavonoids, terpenoids and kavalactones which have been used in folk medicine to treat, for example, arterial hypertension and inflammatory processes. In addition, such species are also used in multidisciplinary studies, including phytochemistry, ethnobotany and biology, indicating the key pharmacological role of this genus in everyday life. Therefore, this work aims to present a bibliographic review of the genus Alpinia and its significance in therapeutic applications.

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“…[27] Compounds found in leaves of Alpinia include flavonoids, [10], [28] phenolic acids, [29] labdane-type diterpenes, [30] diarylheptanoids, [31] phenylbutanoids [32] and kava pyrones. [10], [33], [34] From the leaves of A. zerumbet, flavonoids (rutin, kaempferol 3-O-rutinoside, kaempferol 3-O-glucuronide, (+)-catechin and (-)-epicatechin), and kava pyrones (dihydro-5,6-dehydro kawain and 5,6-dehydrokawain) have been identified. [10] Ferulic acid and p-hydroxybenzoic acid are major phenolic acids in ethyl acetate leaf extracts of A. zerumbet.…”

Section: Wwwantioxorgmentioning

confidence: 99%