GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle

Hudaib, Mohammad; Speroni, Ester; Pietra, Anna Maria Di; Cavrini, Vanni

doi:10.1016/s0731-7085(02)00119-x

Cited by 264 publications

(176 citation statements)

References 17 publications

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“…On the other hand, chemical profile of our T. vulgaris essential oil sample is in agreement with several other reports (Hudaib et al, 2002;Ghasemi et al, 2013), also reporting the thymol as a major constituent of this species oil.…”

Section: The Results Obtained By Chemical Analysis By Gc-ms Of T Sersupporting

confidence: 93%

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Nikolić

Glamočlija

Ferreira³

et al. 2014

Industrial Crops and Products

317

160

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Aromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oil (thyme oil): antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. Oil is also beneficial in boosting the immune system, and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris was performed. GC/MS analysis revealed thymol as major component of T. algeriensis, T. vulgaris and T.serpyllum, with a contribution of 56.02%, 48.92% and 38.50%, respectively. The three essential oils (EOs) exhibited a significant antimicrobial activity against all the tested strains, T. serpyllum oil being the most potent (MIC 2.5-5 µg/mL, MBC 5-10 µg/mL; MIC 1-2 µg/mL, MFC 2-4 µg/mL). In addition, T. serpyllum oil revealed the highest antioxidant activity in all the assays and was also the most effective one against all the tested cell lines, presenting GI 50 values of 7.02-52.69 µg/mL. Moreover, the EOs did not show any toxicity, at the tested concentrations (<400 µg/mL), for porcine liver primary cell culture. In addition to their traditional use in food and cosmetics, the great potential of the tested Thymus essential oils for application in oral disease and anticancer treatments, encourage further investigation.

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Section: The Results Obtained By Chemical Analysis By Gc-ms Of T Sersupporting

confidence: 93%

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Nikolić

Glamočlija

Ferreira³

et al. 2014

Industrial Crops and Products

317

160

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“…The essential oil chemical composition of these plants is said to be influenced by a large set of factors, including edaphic (10,11) and phenological ones (9). But in some populations with the same climatic characteristics there is no correlation between climate and the chemical composition of the oils; for this reason, in other studies carried out on Thymus (12) or other Labiatae (1) climate had less influence on the composition of the essential oils.…”

Section: Climatic Influencementioning

confidence: 99%

“…However, the chemical composition of the essential oils is regulated by a wide group of factors ranging from edafic ones (10,11) to phenological (9) or genetic ones (19) that act on the plants making them different. Some of these factors influence with higher or lower intensity the chemical composition of the essential oils inside a population or area with the same climatic conditions, for example.…”

Section: Phenological Variationmentioning

confidence: 99%

“…Several researchers (5)(6)(7)(8) have stated that the composition of the essential oils extracted from Thymus plants depends on the species, variety and the environmental and ecological characteristics of the area where these plants grow. For Thymus vulgaris, an increase in the yield and concentration of phenolic compounds in summer time has been observed, an important piece of data to consider regarding the quality of the oils collected (9).…”

Section: Introductionmentioning

confidence: 99%

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Bioclimatic influence on essential oil composition in South Iberian Peninsular populations ofThymus zygis

Pérez-Sánchez

Gálvez²,

Ubera

2012

Journal of Essential Oil Research

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The variation in yield and essential oil composition of some plants of Thymus zygis was studied through their life cycle. The relationship between the concentration of the essential oils' main compounds and the most frequently used bioclimatic indices was stated. Individual samples from seven populations growing wild in the South Iberian Peninsula were studied to assess the phenological variation of their oils. The samples showed a maximum yield at the flowering stage. The most representative compounds were selected, statistically analyzed and clustered in two groups, called thymol and c-terpinene according to their behavior through the cycle of the plants studied.

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“…The family of Thymus genus (Lamiaceae family) is among the most popular plants worldwide, commonly used as herbal teas, flavoring agents (condiment and spice), aromatic and medicinal plants (6). Furthermore, the essential oil and extract of different Thymus species are widely used in pharmaceutical, cosmetic and perfume industry, as well as for flavoring and preservation of several food products (7).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Thymus caramanicus Jalas on Human Oral Epidermoid Carcinoma KB Cells

et al. 2017

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Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. Thymus caramanicus Jalas (Lamiaceae family) is one of the species of Thymus that grows wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diabetes, arthritis and cancer. Here was investigated the cytotoxic property of Thymus caramanicus essential oil and extract in human oral epidermoid carcinoma KB cells. Cell viability was measured by MTT and neutral red assays. The cells were exposed to different concentrations of essential oil (0.05-1 µL/mL) and extract (25-150 µg/mL) for 24 h. Doxorubicin was used as anticancer control drug. The data showed that the essential oil (IC50=0.44 µL/mL) and extract (IC50=105 µg/mL) induce potent cytotoxic property. Surprisingly, cytotoxic effects of essential oil and extract of this plant on KB cancer cells were greater than those on normal gingival HGF1-PI1 cell line. In addition, Thymus caramanicus could potentiate the effect of doxorubicin in subeffective concentrations. The results of the present study indicate that essential oils and extracts of Thymus caramanicus have potential anti-proliferative property on KB cells and can be used as pharmaceutical case study for oral cancer treatments.

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GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle

Cited by 264 publications

References 17 publications

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils

Bioclimatic influence on essential oil composition in South Iberian Peninsular populations ofThymus zygis

Cytotoxic Effect of Thymus caramanicus Jalas on Human Oral Epidermoid Carcinoma KB Cells

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