GC–MS fingerprints of essential oils from agarwood grown in wild and artificial environments

Tian, Cheng‐piao; Yao, Xingdong; Lu, Jia-Hao; Shen, Liqun; Wu, Anxin

doi:10.1007/s00468-021-02177-w

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…using HD 13,31,37 . Further, most of these compounds are responsible for the superior quality of agarwood and exhibit various pharmacological activities 37 .…”

Section: Chemical Composition Analysismentioning

confidence: 99%

“…Major compounds detected in this study were consistent with those found in previously published works, wherein the AEO was extracted from Aquilaria spp. using HD 13,31,37 . Further, most of these compounds are responsible for the superior quality of agarwood and exhibit various pharmacological activities 37 .…”

Section: Chemical Composition Analysismentioning

confidence: 99%

“…Ismail et al 41 concluded 10-epi-ϒ-eudesmol, aromadendrane, β-agarofuran, αagarofuran and γ-eudesmol as the marker compounds in high quality agarwood oils derived from A. malaccensis. The presence of four characteristic compounds (benzylacetone, agarospirol, aristolene, and guaiol) has been used as quality indicators for AEO (A. sinensis) in a study conducted by Tian et al 37 . The majority of these compounds, except benzylacetone and aristolene, were present in substantial quantities in the AEO, further con rming the studied sample as a high value fragrant material.…”

Section: Chemical Composition Analysismentioning

confidence: 99%

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Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chan,

Lakeh,

Wang

et al. 2024

Preprint

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Agarwood essential oil (AEO) has gained attention from healthcare industries due to its numerous pharmacological properties. However, a comprehensive understanding of the chemical composition and its cytotoxic property is lacking. The objective of this study was to investigate the chemical profile as well as the cytotoxic concentration range of AEO derived from Aquilaria sinensis wood. Gas chromatography-mass spectrometry (GC-MS) was employed to identify the AEO components. Results showed that sesquiterpenes and sesquiterpenoids constitute 95.85% of the AEO. Among the major compounds identified are allo-aromadendrene (13.04%), dihydro-eudesmol (8.81%), α-eudesmol (8.48%), bulnesol (7.63%), τ-cadinol (4.95%), dehydrofukinone (3.83%), valerenol (3.54%), cis-nerolidol (2.75%), agarospirol (2.72%), dehydrojinkoh-eremol (2.53%), selina-3,11-dien-9-al (2.36%), guaiol (2.12%) and caryophyllene oxide (2.0%). The presence of volatile quality marker compounds such as 10-epi-ϒ-eudesmol, aromadendrane, β-agarofuran, α-agarofuran, γ-eudesmol, agarospirol and guaiol, indicates that the extracted AEO is of premium grade. Interestingly, the AEO displayed moderate to high toxicity in brine shrimp lethality test (BLST). All studied tumor cell lines (MDA-MB-231, HepG2, B16F10) exhibited varying degrees of sensitivity to AEO, which resulted in time and dose-dependent reduction of cell proliferation. Our findings showed that AEO contains bioactive components that may be exploited in future studies for the development of anti-cancer therapeutics.

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“…using HD 13,31,37 . Further, most of these compounds are responsible for the superior quality of agarwood and exhibit various pharmacological activities 37 .…”

Section: Chemical Composition Analysismentioning

confidence: 99%

Section: Chemical Composition Analysismentioning

confidence: 99%

Section: Chemical Composition Analysismentioning

confidence: 99%

See 1 more Smart Citation

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chan,

Lakeh,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Now all Aquilaria species are listed in Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora ( CITES, 2005 ). Due to the reduction of wild trees, Hainan, Guangdong, Guangxi and some other regions began to cultivate A. sinensis plantations at the end of the last century ( Tian et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Anatomical, chemical and endophytic fungal diversity of a Qi-Nan clone of Aquilaria sinensis (Lour.) Spreng with different induction times

Li,

Fang,

Cui

et al. 2024

Front. Plant Sci.

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Recently, some new Qi-Nan clones of Aquilaria sinensis (Lour.) Spreng which intensively produces high-quality agarwood have been identified and propagated through grafting techniques. Previous studies have primarily focused on ordinary A. sinensis and the differences in composition when compared to Qi-Nan and ordinary A. sinensis. There are few studies on the formation mechanism of Qi-Nan agarwood and the dynamic changes in components and endophytic fungi during the induction process. In this paper, the characteristics, chemical composition, and changes in endophytic fungi of Qi-Nan agarwood induced after 1 year, 2 years, and 3 years were studied, and Qi-Nan white wood was used as the control. The results showed that the yield of Qi-Nan agarwood continued to increase with the induction time over a period of 3 years, while the content of alcohol extract from Qi-Nan agarwood reached its peak at two years. During the formation of agarwood, starch and soluble sugars in xylem rays and interxylary phloem are consumed and reduced. Most of the oily substances in agarwood were filled in xylem ray cells and interxylary phloem, and a small amount was filled in xylem vessels. The main components of Qi-Nan agarwood are also chromones and sesquiterpenes. With an increasing induction time, the content of sesquiterpenes increased, while the content of chromones decreased. The most abundant chromones in Qi-Nan agarwood were 2-(2-Phenethyl) chromone, 2-[2-(3-Methoxy-4-hydroxyphenyl) ethyl] chromone, and2-[2-(4-Methoxyphenyl) ethyl] chromone. Significant differences were observed in the species of the endophytic fungi found in Qi-Nan agarwood at different induction times. A total of 4 phyla, 73 orders, and 448 genera were found in Qi-Nan agarwood dominated by Ascomycota and Basidiomycota. Different induction times had a significant effect on the diversity of the endophytic fungal community in Qi-Nan. After the induction of agarwood formation, the diversity of Qi-Nan endophytic fungi decreased. Correlation analysis showed that there was a significant positive correlation between endophytic fungi and the yield, alcohol extract content, sesquiterpene content, and chromone content of Qi-Nan agarwood, which indicated that endophytic fungi play a role in promoting the formation of Qi-Nan agarwood. Qi-Nan agarwood produced at different induction times exhibited strong antioxidant capacity. DPPH free radical scavenging activity and reactive oxygen species clearance activity were significantly positively correlated with the content of sesquiterpenes and chromones in Qi-Nan agarwood.

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Determination of Antitumor Active Ingredients in Agarwood Essential Oil by Gas Chromatography-Mass Spectrometry (GC-MS) and Grey Relational Analysis

Zhang,

Wu,

Zhang

et al. 2024

Analytical Letters

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GC–MS fingerprints of essential oils from agarwood grown in wild and artificial environments

Cited by 4 publications

References 31 publications

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Chemical profiling and cytotoxicity screening of agarwood essential oil (Aquilaria sinensis) in brine shrimp nauplii and cancer cell lines

Anatomical, chemical and endophytic fungal diversity of a Qi-Nan clone of Aquilaria sinensis (Lour.) Spreng with different induction times

Determination of Antitumor Active Ingredients in Agarwood Essential Oil by Gas Chromatography-Mass Spectrometry (GC-MS) and Grey Relational Analysis

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