GCN5 modulates trichome initiation in Arabidopsis by manipulating histone acetylation of core trichome initiation regulator genes

Wang, Tianya; Jia, Qiming; Wang, Wei; Hussain, Saddam; Ahmed, Sajjad; Adnan, Md.; Zhou, Dao‐Xiu; Wang, Shucai

doi:10.1007/s00299-019-02404-2

Cited by 29 publications

(23 citation statements)

References 56 publications

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“…In addition, analyses of chromatin immunoprecipitation suggest that these genes are the specific targets of GCN5. In agreement, Wang et al [224] showed that GCN5-mediated H3K14/K9 acetylation levels on the Transcription Start Site (TSS) motifs of the same genes are declined.…”

Section: Epigenetic Factors Involved In Trichome Developmentsupporting

confidence: 53%

“…Both the GCN5 and ADA2 genes play a critical role in regulating metazoan growth and development. A recent investigation demonstrated that GCN5 acts in the control of trichome initiation and outgrowths through the variation of transcription activities of specific genes by means of H3K9/14 acetylation [224]. In fact, trichomatous cell density enhances in a genotype of Arabidopsis defective of GCN5 gene function.…”

Section: Epigenetic Factors Involved In Trichome Developmentmentioning

confidence: 99%

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The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves

Fambrini

Pugliesi

2019

Plants

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Plant trichomes are outgrowths developed from an epidermal pavement cells of leaves and other organs. Trichomes (also called ‘hairs’) play well-recognized roles in defense against insect herbivores, forming a physical barrier that obstructs insect movement and mediating chemical defenses. In addition, trichomes can act as a mechanosensory switch, transducing mechanical stimuli (e.g., insect movement) into physiological signals, helping the plant to respond to insect attacks. Hairs can also modulate plant responses to abiotic stresses, such as water loss, an excess of light and temperature, and reflect light to protect plants against UV radiation. The structure of trichomes is species-specific and this trait is generally related to their function. These outgrowths are easily analyzed and their origin represents an outstanding subject to study epidermal cell fate and patterning in plant organs. In leaves, the developmental control of the trichomatous complement has highlighted a regulatory network based on four fundamental elements: (i) genes that activate and/or modify the normal cell cycle of epidermal pavement cells (i.e., endoreduplication cycles); (ii) transcription factors that create an activator/repressor complex with a central role in determining cell fate, initiation, and differentiation of an epidermal cell in trichomes; (iii) evidence that underlines the interplay of the aforesaid complex with different classes of phytohormones; (iv) epigenetic mechanisms involved in trichome development. Here, we reviewed the role of genes in the development of trichomes, as well as the interaction between genes and hormones. Furthermore, we reported basic studies about the regulation of the cell cycle and the complexity of trichomes. Finally, this review focused on the epigenetic factors involved in the initiation and development of hairs, mainly on leaves.

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Section: Epigenetic Factors Involved In Trichome Developmentsupporting

confidence: 53%

Section: Epigenetic Factors Involved In Trichome Developmentmentioning

confidence: 99%

The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves

Fambrini

Pugliesi

2019

Plants

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“…A recent study showed that a multifunctional histone acetyltransferase, AtGCN5, positively influences trichome branching with possible regulation of TRY (Kotak et al ., ). On the other hand, through regulating histone acetylation of the promoters of GL1, GL2, GL3 and CPC, GCN5 is also involved trichome initiation regulation (Wang et al ., ). Cell‐free degradation, in planta assays, and mutant analysis showed that ubiquitin protein ligase3 (UPL3) promoted the degradation of GL3 and EGL3, which in turn inhibited trichome branching (Patra et al ., ) (Figure ).…”

Section: Epigenetic Modifications Underlying Trichome Development In mentioning

confidence: 97%

Updates on molecular mechanisms in the development of branched trichome in Arabidopsis and nonbranched in cotton

Wang

Yang

2019

Plant Biotechnology Journal

125

111

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Summary Trichomes are specialized epidermal cells and a vital plant organ that protect plants from various harms and provide valuable resources for plant development and use. Some key genes related to trichomes have been identified in the model plant Arabidopsis thaliana through glabrous mutants and gene cloning, and the hub MYB ‐ bHLH ‐ WD 40, consisting of several factors including GLABRA 1 ( GL 1), GL 3, TRANSPARENT TESTA GLABRA 1 ( TTG 1), and ENHANCER OF GLABRA 3 ( EGL 3), has been established. Subsequently, some upstream transcription factors, phytohormones and epigenetic modification factors have also been studied in depth. In cotton, a very important fibre and oil crop globally, in addition to the key MYB ‐like factors, more important regulators and potential molecular mechanisms (e.g. epigenetic modifiers, distinct metabolic pathways) are being exploited during different fibre developmental stages. This occurs due to increased cotton research, resulting in the discovery of more complex regulation mechanisms from the allotetraploid genome of cotton. In addition, some conservative as well as specific mediators are involved in trichome development in other species. This study summarizes molecular mechanisms in trichome development and provides a detailed comparison of the similarities and differences between Arabidopsis and cotton, analyses the possible reasons for the discrepancy in identification of regulators, and raises future questions and foci for understanding trichome development in more detail.

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“…A recent study reported that the Arabidopsis histone acetyl-transferase GENERAL CONTROL NON-REPRESSED PROTEIN5 (GCN5) is involved in the regulation of trichome initiation (Wang et al, 2019). Loss of function mutants of gcn5 display a low trichome density phenotype and decreased H3Ac levels on GL1, GL3, and GL2 (Wang et al, 2019). On the other hand, it was reported that the histone deacetylase HDA6 can also affect the gene expression and H3Ac level of GL2 (Li et al, 2015).…”

Section: Gl1-r1mentioning

confidence: 99%

Arabidopsis JMJ29 is involved in trichome development by regulating the core trichome initiation gene GLABRA3

et al. 2020

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Summary Plant trichomes are large single cells that are organized in a regular pattern and play multiple biological functions. In Arabidopsis, trichome development is mainly governed by the core trichome initiation regulators, including the R2R3 type MYB transcript factor GLABRA 1 (GL1), bHLH transcript factors GLABRA 3/ENHANCER OF GLABRA 3 (GL3/EGL3), and the WD‐40 repeat protein TRANSPARENT TESTA GLABRA 1 (TTG1), as well as the downstream trichome regulator GLABRA 2 (GL2). GL1, GL3/EGL3, and TTG1 can form a trimeric activation complex to activate GL2, which is required for the trichome initiation and maintenance during cell differentiation. Arabidopsis JMJ29 is a JmjC domain‐containing histone demethylase belonging to the JHDM2/KDM3 group. Members of the JHDM2/KDM3 group histone demethylases are mainly responsible for the H3K9me1/2 demethylation. In the present study, we found that the trichome density on leaves and inflorescence stems is significantly decreased in jmj29 mutants. The expression of the core trichome regulators GL1, GL2, and GL3 is decreased in jmj29 mutants as well. Furthermore, JMJ29 can directly target GL3 and remove H3K9me2 on the GL3 locus. Collectively, we found that Arabidopsis JMJ29 is involved in trichome development by directly regulating GL3 expression. These results provide further insights into the molecular mechanism of epigenetic regulation in Arabidopsis trichome development.

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GCN5 modulates trichome initiation in Arabidopsis by manipulating histone acetylation of core trichome initiation regulator genes

Cited by 29 publications

References 56 publications

The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves

The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves

Updates on molecular mechanisms in the development of branched trichome in Arabidopsis and nonbranched in cotton

Arabidopsis JMJ29 is involved in trichome development by regulating the core trichome initiation gene GLABRA3

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