Gd-DTPA-loaded polymer–metal complex micelles with high relaxivity for MR cancer imaging

Mi, Peng; Cabral, Horacio; Kokuryo, Daisuke; Rafi, Mohammad; Terada, Yasuko; Aoki, Ichio; Saga, Tsuneo; Ishii, Takehiko; Nishiyama, Nobuhiro; Kataoka, Kazunori

doi:10.1016/j.biomaterials.2012.09.030

Cited by 103 publications

(56 citation statements)

References 38 publications

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“…4). This in vivo MR imaging efficacy is comparable with that of other Gd-based nanoparticles reported recently [26,36]. …”

Section: Resultssupporting

confidence: 88%

“…In that respect, and others, the design of formulations for tumor diagnosis may differ from that for tracking therapeutic agents.) The integration of Gd(III) complexes with nanoparticles, such as inorganic nanoparticles [22,23], polymeric nanoparticles [24–26], liposomes [27], and lipid nanoparticles [28,29], has the potential to improve the accumulation of contrast agents due to the EPR effect, and thus to enhance the signal intensities for tumor imaging. Theranostic nanoparticles have been developed that combine a cancer therapeutic (e.g., gemcitabine), with Gd(III) based MRI contrast agents [30,31].…”

Section: Introductionmentioning

confidence: 99%

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Self-assembled gemcitabine–gadolinium nanoparticles for magnetic resonance imaging and cancer therapy

Tong

et al. 2016

Acta Biomaterialia

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Nanoparticles with combined diagnostic and therapeutic functions are promising tools for cancer diagnosis and treatment. Here, we demonstrate a theranostic nanoparticle that integrates an active gemcitabine metabolite and a gadolinium-based magnetic resonance imaging agent via a facile supramolecular self-assembly synthesis, where the anti-cancer drug gemcitabine-5′-monophosphate (a phosphorylated active metabolite of the anti-cancer drug gemcitabine) was used to coordinate with Gd(III) to self-assemble into theranostic nanoparticles. The formulation exhibits a strong T1 contrast signal for magnetic resonance imaging of tumors in vivo, with enhanced retention time. Furthermore, the nanoparticles did not require other inert nanocarriers or excipients and thus had an exceptionally high drug loading (55 wt%), resulting in the inhibition of MDA-MB-231 tumor growth in mice.

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“…4). This in vivo MR imaging efficacy is comparable with that of other Gd-based nanoparticles reported recently [26,36]. …”

Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Self-assembled gemcitabine–gadolinium nanoparticles for magnetic resonance imaging and cancer therapy

Tong

et al. 2016

Acta Biomaterialia

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“…[11] Some polymeric micelles derived from the self-assembly of Gd-DTPA, Pt pharmacophores, and block copolymers, such as PEG-b-P(Glu) and PEG-b-PAsp(DET), have been developed as theranostic agents. [12] Interestingly, a Pt-Gd complex containing Gd-DTPA and {Pt II (2,2':6',2''-terpyridine)} units was shown to selectively accumulate in the nuclei of tumor cells. [13] We herein report two Pt-Gd complexes, 1 and 2, as cancer theranostic agents (Scheme 1).…”

Section: (Py)cl]mentioning

confidence: 99%

Platinum(II)–Gadolinium(III) Complexes as Potential Single‐Molecular Theranostic Agents for Cancer Treatment

Zhu

Wang

et al. 2014

Angew Chem Int Ed

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Theranostic agents are emerging multifunctional molecules capable of simultaneous therapy and diagnosis of diseases. We found that platinum(II)-gadolinium(III) complexes with the formula [{Pt(NH3)2Cl}2GdL](NO3)2 possess such properties. The Gd center is stable in solution and the cytoplasm, whereas the Pt centers undergo ligand substitution in cancer cells. The Pt units interact with DNA and significantly promote the cellular uptake of Gd complexes. The cytotoxicity of the Pt-Gd complexes is comparable to that of cisplatin at high concentrations (≥0.1 mM), and their proton relaxivity is higher than that of the commercial magnetic resonance imaging (MRI) contrast agent Gd-DTPA. T1-weighted MRI on B6 mice demonstrated that these complexes can reveal the accumulation of platinum drugs in vivo. Their cytotoxicity and imaging capabilities make the Pt-Gd complexes promising theranostic agents for cancer treatment.

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“…78 However, most of the clinical contrast agents such as Gd-DTPA, Gd-DOTA, etc., are small molecules with the typical drawbacks of nonspecificity and rapid excretion in vivo. 78 The integration of a small molecule Gd complex-based contrast agent with polymeric assemblies can significantly prolong the half-life of the agent and improve the imaging effect. It can also be extended to be an excellent candidate for real-time monitoring of the drug delivery processes.…”

Section: Polymeric Theranostics For Mri and Drug Deliverymentioning

confidence: 99%

Polymeric Nanosystems for Targeted Theranostics

Li¹,

Wen²,

Dong³

et al. 2016

Nanomaterials for Tumor Targeting Theranostics

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Past several years have seen extensive developments of a variety of theranostic nanosystems. Significant advances on polymeric theranostic nanosystem have been made in image-guided drug delivery taking advantage of the versatility, adaptability and biocompatibility of the rationally designed polymers. In this chapter, the critical issues confronted in the design, synthesis, and characterization of polymeric nanosystem are addressed. An overview is further given on the applications of polymeric nanosystem in biomedicine. In particular, the discussions are focused on some of the key elements of theranostics in terms of fluorescent imaging, drug storage, and controlled delivery. Some novel drug release behavior based on intelligent triggering mechanisms is also discussed. IntroductionThe cure of the cancer critically depends on the early detection and timely medical treatment. The survival rate of patients with breast cancer is approximately 90 %, if it can be diagnosed at an early stage before occurrence of metastasis to distant tissues, organs or lymph nodes. In contrast, the survival rate significantly decreases to 20%, if discovered at a later stage.

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Gd-DTPA-loaded polymer–metal complex micelles with high relaxivity for MR cancer imaging

Cited by 103 publications

References 38 publications

Self-assembled gemcitabine–gadolinium nanoparticles for magnetic resonance imaging and cancer therapy

Self-assembled gemcitabine–gadolinium nanoparticles for magnetic resonance imaging and cancer therapy

Platinum(II)–Gadolinium(III) Complexes as Potential Single‐Molecular Theranostic Agents for Cancer Treatment

Polymeric Nanosystems for Targeted Theranostics

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