GDF-15 A potential Biomarker of Diabetic Nephropathy in Iraq Patients with Chronic Kidney Disease

doi:10.26538/tjnpr/v4i12.9

Cited by 1 publication

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References 21 publications

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“…1 One potential strategy for preventing or treating diabetic nephrotoxicity is using natural compounds. 2 EGFR is a transmembrane receptor protein that is crucial in regulating cell proliferation, survival, and differentiation. Previous studies have shown that EGFR signaling is altered in diabetic nephropathy and may contribute to the development and progression of diabetic kidney disease (DKD).…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effects of Spirulina platensis on NRK-52E Cell Line: LC-HRMS and Docking Studies Targeting Epidermal Growth Factor Receptor

2023

TJNPR

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Previous studies have indicated that algae such as Chlorella vulgaris, Ulva lactuca, and Porphyra yezoensis exhibit potential nephroprotective effects in the context of diabetic kidney disease. 5,6,7 These algae contain common metabolites such as phycocyanin, chlorophyll, carotenoids, vitamins, minerals, polysaccharides, and essential fatty acids. These metabolites, known for their antioxidant properties, have been suggested to play a role in attenuating oxidative stress and inflammation in the kidneys, thereby potentially contributing to the management of diabetic kidney disease. 8,9,10,11 Spirulina platensis is a blue-green alga shown in previous studies to have various potential health benefits, including antioxidant, antiinflammatory, and anti-diabetic effects. 12 NRK-52E cell lines have been widely used as a model system for studying renal epithelial cell biology and kidney disease. The study was aim to investigate the potential nephroprotective effects of Spirulina platensis on NRK-52E cell lines. 13,14 To further investigate the potential molecular mechanisms underlying the effects of Spirulina platensis extract, LC-HRMS was used to identify the phytochemical compounds in the extracts and followed by docking studies using EGFR as a target protein to predict the potential binding interactions between the active compounds. Overall, this study will provide important insights into the potential nephroprotective effects of Spirulina platensis extract in diabetic nephrotoxicity and may help identify novel therapeutic targets and compounds for treating diabetic kidney disease. 15,16

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Section: Introductionmentioning

confidence: 99%

Nephroprotective Effects of Spirulina platensis on NRK-52E Cell Line: LC-HRMS and Docking Studies Targeting Epidermal Growth Factor Receptor

2023

TJNPR

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GDF-15 A potential Biomarker of Diabetic Nephropathy in Iraq Patients with Chronic Kidney Disease

Cited by 1 publication

References 21 publications

Nephroprotective Effects of Spirulina platensis on NRK-52E Cell Line: LC-HRMS and Docking Studies Targeting Epidermal Growth Factor Receptor

Nephroprotective Effects of Spirulina platensis on NRK-52E Cell Line: LC-HRMS and Docking Studies Targeting Epidermal Growth Factor Receptor

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