2012
DOI: 10.1186/1471-230x-12-6
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GDNF protects enteric glia from apoptosis: evidence for an autocrine loop

Abstract: BackgroundEnteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in the regulation of EGC apoptosis.MethodsGDNF expression and EGC apoptosis were determined by immunofluorescence using specimen from CD patients. In primary rat EGC cultures, GDNF receptors were asse… Show more

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Cited by 44 publications
(36 citation statements)
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“…Similarly, gastric electrical stimulation prevented vagotomy‐induced apoptosis of enteric neurons in the stomach, which was mediated by enhanced release of GDNF and activation of its downstream pathway PI3K/Akt . GDNF was also found to protect enteric glial cells from apoptosis induced by gut inflammation through an autocrine mechanism in enteric glial cells …”
Section: Role Of Neurotrophic Factors In Neuroprotection and Neuroplamentioning
confidence: 93%
See 1 more Smart Citation
“…Similarly, gastric electrical stimulation prevented vagotomy‐induced apoptosis of enteric neurons in the stomach, which was mediated by enhanced release of GDNF and activation of its downstream pathway PI3K/Akt . GDNF was also found to protect enteric glial cells from apoptosis induced by gut inflammation through an autocrine mechanism in enteric glial cells …”
Section: Role Of Neurotrophic Factors In Neuroprotection and Neuroplamentioning
confidence: 93%
“…44 GDNF was also found to protect enteric glial cells from apoptosis induced by gut inflammation through an autocrine mechanism in enteric glial cells. 45 Although BDNF has been known to have neuroprotective effects in the central nervous system, the evidence for neuroprotection in the ENS is scarce. BDNF was shown to inhibit inflammation-induced apoptosis in enteric glial cells.…”
Section: Role Of Neurotrophi C Fac Tor S In Neuroprotec Ti On and Nmentioning
confidence: 99%
“…These mediators can increase neuronal as well as epithelial survival. 20,[53][54][55] Altogether, these studies suggest that a similar shift in paradigm could occur for EGCs as for astrocytes in the brain. Indeed, reactive astrocytes of the CNS have long been considered to be deleterious before being increasingly recognized as essential actors of tissue repair after injury.…”
Section: Environmentally Induced Changes In Egc Phenotype: Example Ofmentioning
confidence: 99%
“…Enteric glial cells also function in gut inflammatory processes by increasing the expression of neurotrophic factors such as GDNF, BDNF, and NGF. In IBD, GDNF has an antiapoptotic effect on intestinal epithelial cells and also on enteric glial cells, functioning as a protective feedback loop (Steinkamp et al, ). Another neurotrophic factor with antiapoptotic effects for the enteric glia is BDNF (Steinkamp et al, ).…”
Section: Similar Functions Performed By Enteric Glia and Astrocytesmentioning
confidence: 99%