GE11 peptide-decorated acidity-responsive micelles for improved drug delivery and enhanced combination therapy of metastatic breast cancer

Abstract

Nanotechnology-mediated drug delivery systems suffer from insufficient retention in tumor tissues and unreliable drug release at specific target sites. Herein, we developed an epidermal growth factor receptor-targeted multifunctional micellar nanoplatform...

Effect of zwitterionic sulfobetaine incorporation on blood behaviours, phagocytosis, and in vivo biodistribution of pH-responsive micelles with positive charges

“…The biodistribution of a drug formulation in the body determines whether its payload could accumulate in the target site. 45,46 Although the delivery of NPs benefits from various targeting strategies, including not only passive targeting based on an EPR effect, but also active targeting, such as stimulus responsive, chemokine, and acceptor-ligand mediation approaches, the actual therapeutic efficacy remains not as high as expected. 47 For example, it was reported that less than 10% of the systemically administered dose accumulated within the lesion site, and in many cases there was no significant improvement in patient outcomes.…”

Advances in active targeting of ligand-directed polymeric nanomicelles via exploiting overexpressed cellular receptors for precise nanomedicine

“…To achieve rapid and effective drug accumulation into deep tumor tissues, Guo and his colleagues developed multifunctional targeted nanomicelles for enhanced delivery of combinatorial therapy against metastatic breast cancer via exploiting EGFR. 27 Nanomicelles were fabricated from Mal-PEG-PCL and trimethylene carbonate (TMC) via ring-opening polymerization, then they were co-loaded with cytotoxic DOX and celecoxib (CEL) using esterification reaction and macromolecular self-assembly, respectively to form Mal-PEG/PTMC-DOX-CEL nanomicelles. The exterior of the dual loaded nanomicelles was grafted with GE11 peptide via Schiff's base reaction and click reaction to form GE11/Mal-PEG/PTMC-DOX-CEL nanomicelles.…”