Geant4-DNA simulation of human cancer cells irradiation with helium ion beams

Chatzipapas, Konstantinos; Dordevic, M.; Zivkovic, Sara; Tran, H.N.; Incerti, S.; Sakata, D.; Petrović, Ivan; Ristić-Fira, Aleksandra; Shin, Wook; Zein, Sara A.; Brown, Jeremy M. C.; Kyriakou, Ioanna; Emfietzoglou, Dimitris; Guatelli, Susanna

doi:10.1016/j.ejmp.2023.102613

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…Energetics and spatial characteristics of these generated holes show that carbon ion irradiation indeed generates the largest number of highly energetic holes on the sugar–phosphate side chains but not in a simple trend one might expect from the stopping power. Our first-principles theoretical work here has revealed key details of the DNA electronic excitation under α-particle and carbon ion irradiation in water, yielding atomistic insights into key characteristics associated with heavier ions, particularly carbon ions. ,, These key results contribute to building a comprehensive molecular-level understanding of DNA damage under ion irradiation.…”

Section: Discussionmentioning

confidence: 84%

“…Our first-principles theoretical work here has revealed key details of the DNA electronic excitation under α-particle and carbon ion irradiation in water, yielding atomistic insights into key characteristics associated with heavier ions, particularly carbon ions. 11,83,84 These key results contribute to building a comprehensive molecular-level understanding of DNA damage under ion irradiation.…”

Section: Discussionmentioning

confidence: 97%

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Ion-Type Dependence of DNA Electronic Excitation in Water under Proton, α-Particle, and Carbon Ion Irradiation: A First-Principles Simulation Study

Shepard,

Kanai

2023

J. Phys. Chem. B

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 97%

Ion-Type Dependence of DNA Electronic Excitation in Water under Proton, α-Particle, and Carbon Ion Irradiation: A First-Principles Simulation Study

Shepard,

Kanai

2023

J. Phys. Chem. B

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“…This tool allowed us to simulate the irradiation of human fibroblast cells and the resulting damage to the three DNA conformations. [ 19 ] By calculating the yields of DSBs and single‐strand breaks, which represented both direct and indirect early DNA damage, we quantified and compared the differences in X‐ray‐induced damage for three DNA conformations. Notably, the highest DSB yields were obtained in the Z‐DNA conformation, with DSBs yielding 1.56‐fold higher than the other two DNA conformations ( Figure a; and Table S1, Supporting Information), implying the higher radiosensitivity in Z‐DNA conformation.…”

Section: Resultsmentioning

confidence: 99%

Manipulating Radiation‐Sensitive Z‐DNA Conformation for Enhanced Radiotherapy

Wang,

Liao,

Zeng

et al. 2024

Advanced Materials

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DNA double‐strand breaks (DSBs) yield highly determines radiotherapy efficacy. However, improving the inherent radiosensitivity of tumour DNA to promote radiation‐induced DSBs remains a challenge. Using theoretical and experimental models, we discover the underexplored impact of Z‐DNA conformations on radiosensitivity, yielding higher DSBs than other DNA conformations. Thereout, we propose a radiosensitization strategy focused on inducing Z‐DNA conformation, utilizing CBL@HfO2 nanocapsules loaded with a Z‐DNA inducer CBL0137. A hollow mesoporous HfO2 (HM‐HfO2) acts as a delivery and an energy depositor to promote Z‐DNA breakage. The nanocapsule permits the smart DSBs accelerator that triggers its radiosensitization with irradiation stimulation. Impressively, the CBL@HfO2 facilitates the B‐Z DNA conformational transition, augmenting DSBs about 4‐fold stronger than irradiation alone, generating significant tumour suppression with a 30% cure rate. The approach enables DSBs augmentation by improving the inherent radiosensitivity of DNA. As such, it opens up an era of Z‐DNA conformation manipulation in radiotherapy.This article is protected by copyright. All rights reserved

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“…There is a lot of discussion regarding the implementation of physical phantoms to study cell survival in organs and tissues after an irradiation procedure [41,42]. Nevertheless, the cost for such applications needs a significant budget to be included in every laboratory, as well as a multidisciplinary approach combining many different types of expertise.…”

Section: Introductionmentioning

confidence: 99%

Introduction of Hybrid Additive Manufacturing for Producing Multi-Material Artificial Organs for Education and In Vitro Testing

Chatzipapas,

Nika,

Krimpenis

2024

Designs

Self Cite

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The evolution of 3D printing has ushered in accessibility and cost-effectiveness, spanning various industries including biomedical engineering, education, and microfluidics. In biomedical engineering, it encompasses bioprinting tissues, producing prosthetics, porous metal orthopedic implants, and facilitating educational models. Hybrid Additive Manufacturing approaches and, more specifically, the integration of Fused Deposition Modeling (FDM) with bio-inkjet printing offers the advantages of improved accuracy, structural support, and controlled geometry, yet challenges persist in cell survival, interaction, and nutrient delivery within printed structures. The goal of this study was to develop and present a low-cost way to produce physical phantoms of human organs that could be used for research and training, bridging the gap between the use of highly detailed computational phantoms and real-life clinical applications. To this purpose, this study utilized anonymized clinical Computed Tomography (CT) data to create a liver physical model using the Creality Ender-3 printer. Polylactic Acid (PLA), Polyvinyl Alcohol (PVA), and light-bodied silicone (Polysiloxane) materials were employed for printing the liver including its veins and arteries. In brief, PLA was used to create a mold of a liver to be filled with biocompatible light-bodied silicone. Molds of the veins and arteries were printed using PVA and then inserted in the liver model to create empty channel. In addition, the PVA was then washed out by the final product using warm water. Despite minor imperfections due to the printer’s limitations, the final product imitates the computational model accurately enough. Precision adjustments in the design phase compensated for this variation. The proposed novel low-cost 3D printing methodology successfully produced an anatomically accurate liver physical model, presenting promising applications in medical education, research, and surgical planning. Notably, its implications extend to medical training, personalized medicine, and organ transplantation. The technology’s potential includes injection training for medical professionals, personalized anthropomorphic phantoms for radiation therapy, and the future prospect of creating functional living organs for organ transplantation, albeit requiring significant interdisciplinary collaboration and financial investment. This technique, while showcasing immense potential in biomedical applications, requires further advancements and interdisciplinary cooperation for its optimal utilization in revolutionizing medical science and benefiting patient healthcare.

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Geant4-DNA simulation of human cancer cells irradiation with helium ion beams

Cited by 10 publications

References 42 publications

Ion-Type Dependence of DNA Electronic Excitation in Water under Proton, α-Particle, and Carbon Ion Irradiation: A First-Principles Simulation Study

Ion-Type Dependence of DNA Electronic Excitation in Water under Proton, α-Particle, and Carbon Ion Irradiation: A First-Principles Simulation Study

Manipulating Radiation‐Sensitive Z‐DNA Conformation for Enhanced Radiotherapy

Introduction of Hybrid Additive Manufacturing for Producing Multi-Material Artificial Organs for Education and In Vitro Testing

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