Motorcyclist safety remains a significant problem, and the overall safety of motorcyclists has been improved at a much slower rate in the last decade compared to passenger and commercial vehicles. Because motorcyclists are not protected by the vehicle frame, fatalities or severe injuries are often related to hitting a roadside object or safety barrier. The main objective of this study is to investigate relations between the presence and type of road safety barriers and the consequences of motorcycle crashes on rural roads. For this purpose, we analysed Croatian rural road-crash data from 2015–2019, tested several factors as single predictors, and combined them using binary logistic regression. The results show that run-off-road crashes and nighttime driving are significant risk factors. There was no significant positive impact of the presence of safety barriers on the crash consequences due to the unsuitability of the barriers for motorcyclists, which proves the fact that the functionality of existing safety barriers should be upgraded. The results of this study could be further used by researchers, road designers, and experts to improve road infrastructure safety on rural roads.