Gefäßstudien an der überlebenden Warmblüterleber

Lampe, Walter; Méhes, J.

doi:10.1007/bf01863442

Cited by 10 publications

(3 citation statements)

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“…Such an action is physiologically possible because these veins are richly endowed with smooth muscle. Furthermore, constriction from digitalis has already been demonstrated in perfused livers (3). The constriction in situ would result in pooling of blood in the portal region and thus lowering of the venous pressure, as demonstrated.…”

Section: Digitalis and Strophanthusmentioning

confidence: 70%

“…This cannula was joined to a second water manometer and piston recorder. The changes in a typical experiment were as follows: after the 3, in which splanchnic vasoconstriction predominated. At the heightof the response to the drugs, the smallest increase in portal pressure after digitalis was 37 per cent (dog 1), and the greatest, a rise of 336 per cent after strophanthus (dog 4).…”

Section: Digitalis and Strophanthusmentioning

confidence: 99%

“…This venous action of digitalis agreed with results on the perfused liver and on excised veins reported in the literature. Kobert (2), in 1886, and Lampe and Mehes (3), in 1926, demonstrated that digitalis and allied glucosides caused a marked constriction of the vessels of the perfused liver, and Franklin (4), in 1925, reported constriction of excised veins by digitalis. In our experiments on dogs there was a progressive increase in volume of the liver in-situ and a simultaneous constriction of the intestines after doses of digitalis corresponding to the full therapeutic.…”

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confidence: 99%

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Further Observations on the Circulatory Actions of Digitalis and Strophanthus With Special Reference to the Liver, and Comparisons With Histamine and Epinephrine

Tainter¹,

Dock²

1930

J. Clin. Invest.

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In a previous paper (1) it was shown that digitalis in dogs caused a fall in venous pressure at the time when the minute volume flow of blood was diminished. This fall in venous pressure, and hence in return flow of blood to the heart, was correlated with a peripheral vasocontrictor action of the digitalis. It was indicated that constriction of the hepatic veins was the major factor in causing a redistribution of blood, with pooling in the splanchnic area. This venous action of digitalis agreed with results on the perfused liver and on excised veins reported in the literature. Kobert (2), in 1886, and Lampe and Mehes (3), in 1926, demonstrated that digitalis and allied glucosides caused a marked constriction of the vessels of the perfused liver, and Franklin (4), in 1925, reported constriction of excised veins by digitalis. In our experiments on dogs there was a progressive increase in volume of the liver in-situ and a simultaneous constriction of the intestines after doses of digitalis corresponding to the full therapeutic. Although the significance of these changes in the splanchnic region were appreciated at the time, it was thought that additional data on the state of the portal circulation were desirable, particularly with reference to confirmation or denial of the constrictor action of digitalis on the hepatic veins. In the present paper, therefore, further experiments on this portal mechanism are presented, the results with digitalis being compared and correlated with those with histamine and epinephrine as controls. DIGITALIS AND STROPHANTHUSThe same tincture of digitalis was used as in our previous experiments (1). The potency was equivalent to 88 mgm. of leaves, or 485

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Section: Digitalis and Strophanthusmentioning

confidence: 70%

Section: Digitalis and Strophanthusmentioning

confidence: 99%

mentioning

confidence: 99%

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