Gefitinib salts/cocrystals with phenolic acids as a promising solid-state approach to improve solubility

Abstract

To employ crystal engineering for the design and synthesize of a series of novel salts/cocrystals incorporating phenolic acids, aiming to modulate the solubility of Gefitinib (GEF), a multifunctional antineoplastic drug....

Stoichiometric Diversity of Caffeine and 4-Hydroxybenzoic Acid Cocrystals in Batchelor Vortex Flow

“…Cocrystallization has become an essential method within the pharmaceutical industry for the modification of the physicochemical properties of active pharmaceutical ingredients (APIs), such as solubility, dissolution rate, bioavailability, and stability. − The existence of cocrystals in various stoichiometries between the same API and coformer can expand the repertoire of possible solid forms for a given API. Consequently, the screening of cocrystals with diverse stoichiometries has garnered considerable attention due to its inherent advantages. − For instance, extensive research on the cocrystallization of caffeine (CAF) with 4-hydroxybenzoic acid (4-HBA) has been conducted using both experimental − and computational methods .…”