Gel Dosimetry with Radio-Fluorogenic Coumarin

Abstract

Abstract:In radiotherapy, accurate deposition of energy to the targeted volume is vital to ensure 9 effective treatment. Gel dosimeters are attractive detection systems, as tissue substitutes with 10 potential to yield three-dimensional dose distributions. Radio-fluorogenesis is creation fluorescent 11 chemical products in response to energy deposition from high-energy radiation. This report shares 12 studies of a radio-fluorogenic gel dosimetry system, gelatin with coumarin-3-carboxlyic acid 13 (C3CA), for the quantification of imparted energy. Aqueous solutions exposed to ionizing radiation 14 result in the production of hydroxyl free radicals through water radiolysis. Interactions between 15 hydroxyl free radicals and coumarin-3-carboxylic acid produce a fluorescent product.