Gel–gel adhesion by tethered polymers

Huang, Yanjiang; Szleifer, Igal; Peppas, Nikolaos A.

doi:10.1063/1.1345723

Cited by 25 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect depends strongly on the molecular weight of the grafted PEG, with grafts comprising shorter chains (2,000 g mol −1 ) penetrating well but those comprising longer chains (10,000 g mol −1 ) penetrating several orders of magnitude more slowly. The field of mucoadhesion has been explored from a polymer science perspective: surface-tethered polymer chains interpenetrate, and entangle within, the mucin polymer network, leading to adhesion associated with entanglement and disentanglement 43 , and longer chains interpenetrate more effectively than shorter ones 44 . These concepts are illustrated in Fig.…”

Section: Materials For Penetrating Mucosal Barriersmentioning

confidence: 99%

Materials engineering for immunomodulation

Hubbell

Thomas

Swartz

2009

Nature

513

428

View full text Add to dashboard Cite

The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intracellular pathways, allowing better control of the way in which antigens are presented to one of the key types of immune cell, T cells. Materials are also being designed as adjuvants, to mimic specific 'danger' signals in order to manipulate the resultant cytokine environment, which influences how antigens are interpreted by T cells. In addition to offering the potential for medical advances, immunomodulatory materials can form well-defined model systems, helping to provide new insight into basic immunobiology.The term 'immunobioengineering' is used to describe efforts by immunologists and engineers to design materials, delivery vehicles and molecules both to manipulate and to better understand the immune system. Examples are the engineering of material surfaces to induce or prevent complement activation, the engineering of adjuvants to activate the immune system, the engineering of antigen or adjuvant carriers for subunit vaccine delivery, and the engineering of microenvironments to determine the interaction kinetics of mature dendritic cells and naive T cells. These advances not only will contribute to prophylactic vaccine strategies for infectious diseases but also are likely to affect immunotherapeutics, particularly for cancer, and new approaches to prevent or treat allergies and autoimmune diseases. The field is rapidly evolving along with advances in our understanding of immunology and is also contributing to our knowledge of basic immunology.In this Review, we describe the current state of immunobioengineering as it intersects with the field of materials science, and we give a perspective on its current and future directions. We focus on materials for immunomodulation, particularly with respect to dendritic-cell modulation. We begin by providing a brief introduction to the targets for delivery: the types of cell that materials are being designed to target, the tissues in which those cells reside, the intracellular compartments within those cells, and the influence that delivery to those particular compartments has on immunological outcome. We then discuss the biomolecular payloads used to activate immune cells and the design of the materials used to deliver those 'danger' signals along with, in the context of vaccination, antigens. Finally, we highlight materials approaches that are being developed to explore basic immunological function, especially how dendritic cells and T cells interact. Tissue and cellular targetsAs the general goals of immunobioengineering are to probe and manipulate the immune system, we start with a general discussion of tissue, cellular and subcellular targets -what we want to target and why -to guide the design principles discussed below.The immune cells most frequently targeted include B cells, macrophages and dendritic cells, wh...

show abstract

Section: Materials For Penetrating Mucosal Barriersmentioning

confidence: 99%

Materials engineering for immunomodulation

Hubbell

Thomas

Swartz

2009

Nature

513

428

View full text Add to dashboard Cite

show abstract

“…Tethered polymer networks have received considerable attention for their use in modifying surface adhesion and friction [1][2][3], drug delivery systems [4][5][6][7][8], and bioadhesives [1,2,9,10]. Biomimetic systems, biomaterials that mimic a biological environment to elicit a desired cellular response [11], have also utilized tethered macromolecules to effectively enhance cellular adhesion [12][13][14] or prevent protein adsorption [15].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of poly(ethylene glycol)-tethered, pH responsive networks

Thomas

Tingsanchali

Rosales

et al. 2007

Polymer

View full text Add to dashboard Cite

Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized using a precipitation polymerization technique. The microparticles were grafted with poly(ethylene glycol) (PEG) chains that are capable of complexing with the hydroxyl groups of the polyacid and interpenetrating into the mucus gel layer upon entry into the small intestine. Upon introduction of an alkaline solution, these materials imbibe a significant amount of water and create a highly viscous suspension. These materials have the necessary physicochemical properties to serve as mucoadhesive controlled release drug carriers for the oral delivery of drugs.

show abstract

“…To solve the simultaneous equations above, we follow the method of I. Szleifer and co-workers [35][36][37][38][39]. The horizontal x-y plane is assumed to be homogeneous.…”

Section: Methodsmentioning

confidence: 99%

Regulation of Cell Adhesion Free Energy by External Sliding Forces

Yang

Zaman

2007

Exp Mech

View full text Add to dashboard Cite

Cells experience a variety of forces and external velocities in vivo. While a number of continuum based models have addressed cell substrate interactions in these dynamic environments, a molecular picture of adhesion under external sliding forces and velocities is lacking. Using a molecular thermodynamic model, that incorporates entropic and steric repulsions, molecular conformations and constraints, penetrable substrates and explicit binding interactions, we study the effect of external sliding velocities on cell adhesion. We map the free energy landscapes under a broad range of external forces, binding energies and receptor surface coverages. Our calculations predict the regimes where free energy landscapes become resistant to external forces. Our model shows good agreement with experimental studies and lays out a scalable framework for analyzing and quantifying a broad spectrum of in vivo and in vitro adhesion studies.

show abstract

Gel–gel adhesion by tethered polymers

Cited by 25 publications

References 31 publications

Materials engineering for immunomodulation

Materials engineering for immunomodulation

Dynamics of poly(ethylene glycol)-tethered, pH responsive networks

Regulation of Cell Adhesion Free Energy by External Sliding Forces

Contact Info

Product

Resources

About