Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C

Abstract

The administration of active compounds by the oral mucosa is an efficient method for the delivery of drugs and nutrients. This work aimed to develop and characterize orally disintegrating films (ODFs) based on starch and gelatin as carriers of vitamin C. The ODFs were produced using a casting technique by varying the concentrations of starch and gelatin (0, 20, 40, 60, 80, and 100 g of starch/100 g of polymer) and were characterized in relation to contact angle, opacity, surface pH, infrared spectroscopy, mechanical properties, morphology, and disintegration time (in vitro and in vivo). Additionally, the stability of vitamin C in the ODFs was evaluated by the incorporation of the dry extract of acerola (4 g/100 g of filmogenic solution). Generally, the ODFs presented hydrophilic characteristics with a neutral surface pH near the mouth, and films with higher starch concentrations showed greater rigidity. In vitro and in vivo tests indicated that ODFs may be classified as rapidly disintegrating. The ODFs produced with higher concentrations of starch showed a higher stability of the active compound, in addition to a shorter disintegration time. Starch‐ and gelatin‐based ODFs can be considered a new system for administering active ingredients via the oral mucosa. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44841.

Spray-drying of fruit and vegetable juices: Effect of drying conditions on the product yield and physical properties

“…Según sean las condiciones del sistema, a través de la degradación de Strecker, el ácido 2,3-dicetogulónico se cicla y produce anhídrido carbónico y furfural; este último se polimeriza y forma las melanoidinas, compuestos responsables del pardeamiento no enzimático. Este mecanismo se complica considerablemente si hay presencia de azucares reductores y aminoácidos que favorecen diversas rutas de degradación (Badui, 2006) En el almacenamiento de polvos de acerola y camucamu obtenidos por SD a 30°C, 75% HR y 30 días; se presentaron reducciones de vitamina C del 78% y 39,5% respectivamente (dos Santos Garcia et al, 2020). En otro estudio se reportó el incremento de la sensibilidad de la vitamina C contenida en microcápsulas en almidón de Taro a 50°C con el incremento de la HR (13,22,46, 57 y 72%) (Hoyos-Leiva et al,2018).…”

Ultrasonic incorporation of cinnamon essential oil into pre-gelatinized cassava starch oral films

“…OFs were produced by casting technique, with constant concentration of pre-gelatinized starch (2g.100g -1 filmogenic solution), according Garcia et al (2017), and doi.org/10.46311/2178-2571 Original Uningá Review, 38, eURJ4448, 2023. glycerol (0.4g.100g -1 pre-gelatinized starch). Initially, the pre-gelatinized starch was solubilized in distilled water for 30 minutes under magnetic stirring (Marconi MA 085).…”

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

“…The delivery of compounds in the form of oral films is widely explored with synthetic active principles; 26,27,30,31 however, the number of works that incorporate natural active compounds is growing such as dry acerola extract in gelatin-based films and pre-gelatinized starch 32,33 gambier leaf extract in films based on chitosan and tapioca starch 34 extract of whaling grass in films based on starch and HPMC, 24 Ginkgo biloba L. extract in CMC-based films, 35 garlic extract in chitosan and maltodextrin based films. 36 Garcia et al 28 produced oral films based on pregelatinized starch and gelatin, and verified that the incorporation of dry camu-camu pulp in the oral films presented high antioxidant capacity.…”