Development of new antibacterial materials for solving biomedical problems is an extremely important and very urgent task. This review aims to summarize recent articles (from the last five and mostly the last three years) on the nanoparticle/polymer composites for biomedical applications. Articles on polymeric nanoparticles (NPs) and hydrogel-based systems were not reviewed, since we focused our attention mostly on the composites of polymeric matrix with at least one inorganic filler in the form of NPs. The fields of application of newly developed antibacterial NPs/polymer composites are described, along with their composition and synthetic approaches that allow researchers to succeed in preparing effective composite materials for medical and healthcare purposes.