Gelatin-coated magnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study

Gaihre, Babita; Khil, Myung-Seob; Lee, Douk Rae; Kim, Hee Young

doi:10.1016/j.ijpharm.2008.08.020

Cited by 216 publications

(95 citation statements)

References 31 publications

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“…In pharmaceuticals, gelatin is normally used in the shells of capsules to make the powdery content easier to transport by ingestion [43] and even engineered nanoparticles have successfully been encapsulated in gelatin nanoparticles or coated with gelatin, with efficient loading and drug release properties [44]. Because of these advantages, the technology of nano-encapsulation has been extended to natural products to protect them from chemical damage and product degradation, especially from air oxidation [45].…”

Section: Resultsmentioning

confidence: 99%

Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Kavitha¹,

Sujatha²,

Manoharan³

2017

J Nanomedine Biotherapeutic Discov

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Section: Resultsmentioning

confidence: 99%

Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Kavitha¹,

Sujatha²,

Manoharan³

2017

J Nanomedine Biotherapeutic Discov

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“…28 Despite the fact that an attractive electrostatic interaction may exist between the positively charged drug molecules and the negatively charged polymeric surface, DOX loading values (%) for the surface adsorption method can be considered relatively low (4%) ( Figure 1C). 29,30 In fact, the approximation of this hydrophilic chemotherapy agent from the aqueous phase to the hydrophobic NP surface is expected to be thermodynamically unfavorable (when considering the decimal logarithm of the partitioning coefficient at pH 5.8 in an n-octanol/water system [log 10 D oct/water ] =-0.45).…”

Section: Discussionmentioning

confidence: 99%

Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles

Cabeza¹,

Ortíz²,

Arias³

et al. 2015

IJN

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The use of doxorubicin (DOX), one of the most effective antitumor molecules in the treatment of metastatic breast cancer, is limited by its low tumor selectivity and its severe side effects. Colloidal carriers based on biodegradable poly(butylcyanoacrylate) nanoparticles (PBCA NPs) may enhance DOX antitumor activity against breast cancer cells, thus allowing a reduction of the effective dose required for antitumor activity and consequently the level of associated toxicity. DOX loading onto PBCA NPs was investigated in this work via both drug entrapment and surface adsorption. Cytotoxicity assays with DOX-loaded NPs were performed in vitro using breast tumor cell lines (MCF-7 human and E0771 mouse cancer cells), and in vivo evaluating antitumor activity in immunocompetent C57BL/6 mice. The entrapment method yielded greater drug loading values and a controlled drug release profile. Neither in vitro nor in vivo cytotoxicity was observed for blank NPs. The 50% inhibitory concentration (IC 50 ) of DOX-loaded PBCA NPs was significantly lower for MCF-7 and E0771 cancer cells (4 and 15 times, respectively) compared with free DOX. Furthermore, DOX-loaded PBCA NPs produced a tumor growth inhibition that was 40% greater than that observed with free DOX, thus reducing DOX toxicity during treatment. These results suggest that DOX-loaded PBCA NPs have great potential for improving the efficacy of DOX therapy against advanced breast cancers.

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“…Whereas magnetic nanobeads are already widely used in biomedical research and applications (Gooneratne et al 2013;Wilhelm et al 2008;Tanaka et al 2008;Gaihre et al 2009;Gonzales-Weimuller et al 2009), magnetic nanowires (NWs) became attractive only recently. The magnetic properties of NWs can be tailored in a wide range, mainly because their diameter and length can be independently modulated (Song et al 2012;Sun et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and intracellular dissolution of nickel nanowires

Perez

Contreras²,

Vilanova

et al. 2016

Nanotoxicology

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The assessment of cytotoxicity of nanostructures is a fundamental step for their development as biomedical tools. As widely used nanostructures, nickel nanowires (Ni NWs) seem promising candidates for such applications. In this work, Ni NWs were synthesized and then characterized using vibrating sample magnetometry, energy dispersive X-Ray analysis and electron microscopy. After exposure to the NWs, cytotoxicity was evaluated in terms of cell viability, cell membrane damage and induced apoptosis/necrosis on the model human cell line HCT 116. The influence of NW to cell ratio (10:1 to 1000:1) and exposure times up to 72 hours was analyzed for Ni NWs of 5.4 µm in length, as well as for Ni ions. The results show that cytotoxicity markedly increases past 24 hours of incubation. Cellular uptake of NWs takes place through the phagocytosis pathway, with a fraction of the dose of NWs dissolved inside the cells. Cell death results from a combination of apoptosis and necrosis, where the latter is the outcome of the secondary necrosis pathway. The cytotoxicity of Ni ions and Ni NWs dissolution studies suggest a synergistic toxicity between NW aspect ratio and dissolved Ni, with the cytotoxic effects markedly increasing after 24 hours of incubation.Just Accepted by Nanotoxicology © 2015 Taylor & Francis. This provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.DISCLAIMER: The ideas and opinions expressed in the journal's Just Accepted articles do not necessarily reflect those of Taylor & Francis (the Publisher), the Editors or the journal. The Publisher does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of the material contained in these articles. The reader is advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify the dosages, the method and duration of administration, and contraindications. It is the responsibility of the treating physician or other health care professional, relying on his or her independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Just Accepted articles have undergone full scientific review but none of the additional editorial preparation, such as copyediting, typesetting, and proofreading, as have articles published in the traditional manner. There may, therefore, be errors in Just Accepted articles that will be corrected in the final print and final online version of the article. Any use of the Just Accepted articles is subject to the express understanding that the papers have not yet gone through the full quality control process prior to publication. Cytotoxicity and intracellular dissolution of nickel nanowiresJose E. Perez 1, 2 , Maria F. Contreras 1 , Enrique Vilanova 2 , Laura P. Felix 1, 2 , Michael B.

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Gelatin-coated magnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study

Cited by 216 publications

References 31 publications

Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles

Cytotoxicity and intracellular dissolution of nickel nanowires

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