2022
DOI: 10.1371/journal.pone.0277561
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Gelatin coating enhances therapeutic cell adhesion to the infarcted myocardium via ECM binding

Abstract: Acute myocardial infarction (AMI) results in weakening of the heart muscle and an increased risk for chronic heart failure. Therapeutic stem cells have been shown to reduce inflammatory signaling and scar tissue expansion, despite most of these studies being limited by poor retention of cells. Gelatin methacrylate (GelMA) coatings have been shown to increase the retention of these therapeutic cells near the infarct. In this work, we evaluate two different potential binding partners for GelMA-coated bone marrow… Show more

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Cited by 5 publications
(2 citation statements)
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“…Our results show that for PC12 cell differentiation, the characteristics of GelMA, like collagen, are favorable. GelMA is recognized as a hydrogel with good surface properties that favor cell adhesion [ 31 ]. However, with alginate and PEGDA, these properties should be optimized by modifying their concentrations or by incorporating molecules that increase the adhesion of proteins that are part of the incorporation of cells on the surfaces [ 32 , 33 ]; this could explain the results obtained.…”
Section: Resultsmentioning
confidence: 99%
“…Our results show that for PC12 cell differentiation, the characteristics of GelMA, like collagen, are favorable. GelMA is recognized as a hydrogel with good surface properties that favor cell adhesion [ 31 ]. However, with alginate and PEGDA, these properties should be optimized by modifying their concentrations or by incorporating molecules that increase the adhesion of proteins that are part of the incorporation of cells on the surfaces [ 32 , 33 ]; this could explain the results obtained.…”
Section: Resultsmentioning
confidence: 99%
“…The lowest cytocompatibility observed in the presence of alginate can be a double-edged weapon since it could represent a valid coating strategy to overcome inflammatory response after implantation ( Serafin et al, 2023 ). To enhance cell adhesion in coating approaches, gelatin has been combined with methacrylate in the so-called GelMA ( Davis et al, 2022 ) and reinforced in either continuous or discontinuous patterns ( Wu et al, 2017 ; Roshanbinfar et al, 2018 ; Zwi-Dantsis et al, 2020 ). Among other glycoconjugates with high translational power, the protein fibrin is particularly attractive for an autologous approach since it can be generated by elements, as fibrinogen, isolated from the patient’s blood ( Schaaf et al, 2011 ; Chang et al, 2022 ).…”
Section: Biomimetic Design: From Extracellular Matrix To Scaffoldmentioning
confidence: 99%