Gelatin content governs hydration induced structural changes in silica-gelatin hybrid aerogels – Implications in drug delivery

Kéri, Mónika; Forgács, Attila; Papp, Vanda; Bányai, István; Veres, Péter; Len, Adél; Dudás, Zoltán; Fábián, István; Kalmár, József

doi:10.1016/j.actbio.2020.01.016

Cited by 55 publications

(40 citation statements)

References 94 publications

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“…Owing to its excellent adhesive ability and biocompatibility, gelatin methacryloyl-dopamine (GelMA-DOPA) has been widely used in bone tissue engineering [31][32][33]. Liposomes, which are well-known for their excellent biocompatibility and satisfactory ability to control drug release, have been widely utilized in various types of drug delivery [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

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Sustained Release of Melatonin from GelMA Liposomes Reduced Osteoblast Apoptosis and Improved Implant Osseointegration in Osteoporosis

Xiao

Lin

Chen

et al. 2020

Oxidative Medicine and Cellular Longevity

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A reduction in bone mass around an implant is the main cause of implant loosening, especially in postmenopausal osteoporosis patients. In osteoporosis, excessive oxidative stress, resulting in osteoblast apoptosis, largely contributes to abnormal bone remodeling. Melatonin (MT) synthesized by the pineal gland promotes osteoblast differentiation and bone formation and has been effectively used to combat oxidative stress. Therefore, we hypothesized that MT attenuates osteoblast apoptosis induced by oxidative stress, promotes osteogenesis in osteoporosis, and improves bone mass around prostheses. Moreover, considering the distribution and metabolism of MT, its systemic administration would require a large amount of MT, increasing the probability of drug side effects, so the local administration of MT is more effective than its systemic administration. In this study, we constructed a composite adhesive hydrogel system (GelMA-DOPA@MT) to bring about sustained MT release in a local area. Additionally, MT-reduced apoptosis caused by hydrogen peroxide- (H2O2-) induced oxidative stress and restored the osteogenic potential of MC3T3-E1 cells. Furthermore, apoptosis in osteoblasts around the implant was significantly attenuated, and increased bone mass around the implant was observed in ovariectomized (OVX) rats treated with this composite system. In conclusion, our results show that GelMA-DOPA@MT can inhibit osteoblast apoptosis caused by oxidative stress, thereby promoting osteogenesis and improving bone quality around a prosthesis. Therefore, this system of local, sustained MT release is a suitable candidate to address implant loosening in patients with osteoporosis.

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Section: Introductionmentioning

confidence: 99%

“…Oxidative Medicine and Cellular Longevity shows satisfactory adhesive properties, biodegradability, and biocompatibility [31][32][33]. Before its exposure to UV light, a precrosslinked GelMA solution could be injected and used to fill the gap between the implant and the cancellous bone [58].…”

mentioning

confidence: 99%

Sustained Release of Melatonin from GelMA Liposomes Reduced Osteoblast Apoptosis and Improved Implant Osseointegration in Osteoporosis

Xiao

Lin

Chen

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…The obtained p exponent in the large Q-range characterizes the interfaces present in the sample, namely the pore-particle surface. The p exponent values for porous structures such as ionogels or aerogels [ 49 ] usually vary between 2 and 4, 4 being specific to smooth interfaces, while values between 3 and 4 correspond to fractal-like, rough surfaces. Values between 2 and 3 characterize mass fractal systems.…”

Section: Discussionmentioning

confidence: 99%

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

et al. 2020

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The Herpes simplex viruses (HSV-1, HSV-2) are responsible for a wide variety of conditions, from cutaneous-mucosal to central nervous system (CNS) infections and occasional infections of the visceral organs, some of them with a lethal end. Acyclovir is often used intravenously, orally, or locally to treat herpetic infections but it must be administered with caution to patients with kidney disease and to children of early age. The main objectives of this study were to synthesize and evaluate new polyurethane nanoparticles that might be used as proper transmembrane carriers for acyclovir. Polyurethane particles were obtained by a polyaddition process: a mixture of two aliphatic diisocyanates used as organic phase was added to a mixture of butanediol and polyethylene glycol used as aqueous phase. Two different samples (with and without acyclovir, respectively) were synthesized and characterized by UV-Vis spectra in order to assess the encapsulation efficacy and the release profile, FT-IR, DSC, SEM, and SANS for structural characterization, as well as skin irritation tests. Nearly homogeneous samples with particle sizes between 78 and 91 nm have been prepared and characterized revealing a medium tendency to form clusters and a high resistance to heat up to 300 °C. The release profile of these nanoparticles is characteristic to a drug delivery system with a late discharge of the loaded active agents. Very slight increases in the level of transepidermal water loss and erythema were found in a 15-day evaluation on human skin. The results suggest the synthesis of a non-irritative carrier with a high encapsulation efficacy that can be successfully used for the transmembrane transfer of acyclovir.

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“…Silica, silica-casein hybrid, silica-gelatin hybrid, Ca-alginate, polyimide, polyamide, Ca(II) crosslinked polyamide and cellulose aerogels were prepared using recipes previously published in the literature [20][21][22][39][40][41][42][43][44][45]. The essential summaries of the synthetic procedures are given in the Supplementary Meterials.…”

Section: Experimental 21 Preparation Of Aerogelsmentioning

confidence: 99%

False Morphology of Aerogels Caused by Gold Coating for SEM Imaging

et al. 2021

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The imaging of non-conducting materials by scanning electron microscopy (SEM) is most often performed after depositing few nanometers thick conductive layers on the samples. It is shown in this work, that even a 5 nm thick sputtered gold layer can dramatically alter the morphology and the surface structure of many different types of aerogels. Silica, polyimide, polyamide, calcium-alginate and cellulose aerogels were imaged in their pristine forms and after gold sputtering utilizing low voltage scanning electron microscopy (LVSEM) in order to reduce charging effects. The morphological features seen in the SEM images of the pristine samples are in excellent agreement with the structural parameters of the aerogels measured by nitrogen adsorption-desorption porosimetry. In contrast, the morphologies of the sputter coated samples are significantly distorted and feature nanostructured gold. These findings point out that extra care should be taken in order to ensure that gold sputtering does not cause morphological artifacts. Otherwise, the application of low voltage scanning electron microscopy even yields high resolution images of pristine non-conducting aerogels.

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Gelatin content governs hydration induced structural changes in silica-gelatin hybrid aerogels – Implications in drug delivery

Cited by 55 publications

References 94 publications

Sustained Release of Melatonin from GelMA Liposomes Reduced Osteoblast Apoptosis and Improved Implant Osseointegration in Osteoporosis

Sustained Release of Melatonin from GelMA Liposomes Reduced Osteoblast Apoptosis and Improved Implant Osseointegration in Osteoporosis

Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir

False Morphology of Aerogels Caused by Gold Coating for SEM Imaging

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