Gelatin grafted Fe3O4 based curcumin nanoformulation for cancer therapy

Dutta, Binay K.; Shelar, Sandeep; Rajan, Vasumathy; Checker, Swati; Divya, .; Barick, K.C.; Pandey, Badri N.; Kumar, Sanjay; Hassan, P. A.

doi:10.1016/j.jddst.2021.102974

Cited by 13 publications

(5 citation statements)

References 45 publications

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“…Many researchers studied gelatin-coated Fe 3 O 4 nanoparticles [ 34 ], and others were working on gelatin grafted with Fe 3 O 4 for applications in combined chemotherapy and hyperthermia. Due to the structure of gelatin molecules on the surface of MNPs, these materials present a hydrophilic behavior and provide sites for the encapsulation of anticancer drugs through hydrophobic interaction [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Drobotă¹,

Vlad²,

Grădinaru³

et al. 2022

Materials

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The majority of recent studies have focused on obtaining MRI materials for internal use. However, this study focuses on a straightforward method for preparing gelatin-based materials with iron oxide nanoparticles (G–Fe2O3 and G–Fe3O4) for external use. The newly obtained materials must be precisely tuned to match the requirements and usage situation because they will be in close touch with human/animal skin. The biocompatible structures formed by gelatin, tannic acid, and iron oxide nanoparticles were investigated by using FTIR spectroscopy, SEM-EDAX analysis, and contact angle methods. The physico-chemical properties were obtained by using mechanical investigations, dynamic vapor sorption analysis, and bulk magnetic determination. The size and shape of iron oxide nanoparticles dictates the magnetic behavior of the gelatin-based samples. The magnetization curves revealed a typical S-shaped superparamagnetic behavior which is evidence of improved MRI image accuracy. In addition, the MTT assay was used to demonstrate the non-toxicity of the samples, and the antibacterial test confirmed satisfactory findings for all G-based materials.

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Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Drobotă¹,

Vlad²,

Grădinaru³

et al. 2022

Materials

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“…A challenge that has been given a lot of attention in this article compared to previous articles (B. Dutta et al, 2022;Nguyen, Luong, Pham, Tran, & Dang, 2022). so that these systems are not toxic against normal body cells and can act as drugs with very low side effects, after studying the impact of treatments on DNA and its digestibility, it was found that curcumin magnetic nanoparticles and curcumin-coated magnetic nanoparticles do not show significant DNA digestion activity.…”

Section: Discussionmentioning

confidence: 90%

Cytotoxicity of curcumin-loaded magnetic nanoparticles against normal and cancer cells as a breast cancer drug delivery system

Alnooj

Ghobadi

Mousavi-Khattat

et al. 2022

Nanofab

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Recently, therapeutic applications of modified magnetic nanoparticles have attracted the attention of many researchers. The reason is the ability to develop nano drugs as cancer treatment agents. For this purpose, these particles must have a tiny size, intrinsic magnetic properties, imaging effectiveness, the ability to target the drug, and high drug absorption. Although studies have been performed on the anti-cancer properties of curcumin/nanoparticles, no comprehensive research has been performed to evaluate its anti-cancer and the normal cell toxicity of this drug system for breast cancer treatment. This study designed a curcumin-loaded MNPs (MNPs@CUR) formulation to accomplish these unique features. Using the diffusion process, chemical precipitation was used to make MNPs, which were then loaded with curcumin (CUR). Transmission electron microscopy (TEM) was used to study the morphology and size of MNP-CUR. The fabricated MNPs had spherical shapes with an average length of 23.22 nm. The presence of curcumin on the surface of MNPs was approved using Fourier transform infrared (FTIR) analysis. The X-ray diffraction (XRD) diffractogram confirmed the face cubic center (fcc) character of MNPs. After 24 hours of incubation with 4t1 breast cancer cells, MNPs@CUR anticancer effects were evaluated. MNPs@CUR displayed a concentration-dependent preference for applying anticancer effects on 4t1cells (IC50=108 µg/ml). Separated in vivo anti-tumor studies of coated/naked nanoparticles and curcumin also demonstrated that MNPs@CUR eliminated tumor mass. The cytotoxicity and genotoxicity against normal peripheral blood mononuclear cells (PBMC) were also measured by 2,5-diphenyl-2H-tetrazolium bromide (MTT) electrophoresis DNA digestion methods respectively for MNPs@CUR and naked MNPs. Cytotoxicity was demonstrated at high concentrations of MNP@CUR (991 µg/ml), while naked nanoparticles showed approximately no toxicity and neither had genotoxicity.

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“…The magnetic nanoparticles that can be used in hyperthermia are categorized into six groups including metal oxide nanoparticles, 43 ferrite nanoparticles, 44,45 metallic nanoparticles, 46 metallic alloyed nanoparticles, 47 core/shell nanoparticles, 48 and metal-doped iron oxide nanoparticles. 3 The ferrites have received attention for hyperthermia treatment due to their superior magnetic properties, low inherent toxicity, easy synthesis, and chemical stability.…”

Section: Nanoparticles Used In Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic hyperthermia in cancer therapy, mechanisms, and recent advances: A review

Molaei

2024

J Biomater Appl

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Hyperthermia therapy refers to the elevating of a region in the body for therapeutic purposes. Different techniques have been applied for hyperthermia therapy including laser, microwave, radiofrequency, ultrasonic, and magnetic nanoparticles and the latter have received great attention in recent years. Magnetic hyperthermia in cancer therapy aims to increase the temperature of the body tissue by locally delivering heat from the magnetic nanoparticles to cancer cells with the aid of an external alternating magnetic field to kill the cancerous cells or prevent their further growth. This review introduces magnetic hyperthermia with magnetic nanoparticles. It includes the mechanism of the operation and magnetism behind the magnetic hyperthermia phenomenon. Different synthesis methods and surface modification to enhance the biocompatibility, water solubility, and stability of the nanoparticles in physiological environments have been discussed. Recent research on versatile types of magnetic nanoparticles with their ability to increase the local temperature has been addressed.

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Gelatin grafted Fe3O4 based curcumin nanoformulation for cancer therapy

Cited by 13 publications

References 45 publications

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Cytotoxicity of curcumin-loaded magnetic nanoparticles against normal and cancer cells as a breast cancer drug delivery system

Magnetic hyperthermia in cancer therapy, mechanisms, and recent advances: A review

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