Gelatin Paste as an Alternative Cost-Effective Hemostatic Agent in Cranial Surgery: Doing More with Less

Serrato-Ávila, Juan Leonardo; Navarro-Fernández, José Omar; Hernández-Reséndiz, Rodrigo Efraín; Cacho-Díaz, Bernardo; Reyes-Soto, Gervith; Monroy-Sosa, Alejandro

doi:10.1016/j.wneu.2018.10.224

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…The time to reach hemostasis is about 5-10 min. Besides conventional hemostatic purpose, it has been suggested that gelatin sponge may be used to self-make an effective and inexpensive flowable gelatin paste, which can be adopted safely in neurosurgery alone or combined with other hemostatics [19,20]. Moreover, an appropriately placed subdural gelatin sponge over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical procedures [18].…”

Section: Gelatin Spongesmentioning

confidence: 99%

The role of hemostatic devices in neurosurgery. A systematic review

Giammalva

Brunasso

Costanzo

et al. 2021

Journal of Clinical Neuroscience

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Hemostasis represents a fundamental step in every surgical procedure. During neurosurgical procedures, proper and robust hemostasis into confined spaces can significantly reduce the odds of perioperative complications. Over the decades, multiple methods have been applied, and several medical devices have been developed to promote and guarantee proper hemostasis. This study presents a systematic review of the most used intraoperative hemostatic methods and devices in neurosurgery. Insightful research was performed on the PubMed database according to the PRISMA guidelines. This comprehensive review of scientific literature represents a synoptic panel where the most used intraoperative hemostatic methods and devices available today in neurosurgery are classified and described.

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Section: Gelatin Spongesmentioning

confidence: 99%

The role of hemostatic devices in neurosurgery. A systematic review

Giammalva

Brunasso

Costanzo

et al. 2021

Journal of Clinical Neuroscience

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“…The low value of sh gelatin may be due to hydroxyproline content being relatively low in sh skin [26]. The hydroxyproline and proline can form hydrogen bonding with free water and triple-helix of gelatin structure [15]. Also, the bloom strength of gelatin is affected by many factors like chemical handling of gelatin, type, form, concentration, and source of gelatin, besides the thermal history of the extracted gelatin [11].…”

Section: Gelatin Composition and Bloom Strength Of Gelatin Gelsmentioning

confidence: 99%

“…Gelatin is known as an extracted protein through a precise hydrolysis process of the insoluble brous of collagen [14]. Skin and bones produced as waste during animal slaughtering and processing are the main sources of collagen [15]. Therefore, gelatin can be considered a low-cost biopolymer with excellent functional lm-forming properties [16].…”

Section: Introductionmentioning

confidence: 99%

Efficient Eco-Friendly Nano-Extracted Gelatin as Biodegradable Packaging Material

Ibrahim

Soliman

2021

Preprint

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Extracted gelatin from the waste of fresh and grilled chicken skin was used to prepare films as a biodegradable packaging material from solutions of various gelatin concentrations using a casting approach. The thermal behavior of extracted gelatins was investigated by differential scanning calorimetric. The particle size and zeta potential of dispersed nanoparticles of gelatins were measured by dynamic light scattering. The surface area of lyophilized gelatin nanoparticles was calculated from the adsorption of N2 gas. Mechanical properties, water vapor permeability (WVP), and oil uptake (OU) of all manufactured films were studied. Tensile strength values significantly increased for films manufactured from both gelatin sources when the concentration increased from 4 % to 6 % up to 5.1 MPa. The elongation of waste skin gelatin-based films was higher than waste grilled skin gelatin (WG)-based films using 4 % and 8 % concentrations up to 57 %. Films manufactured from WG had significantly lower WVP than waste skin gelatin (WS) analogous at a 4 % gelatin concentration. The WVP of films manufactured from gelatin significantly increased as gelatin concentration increased where OU showed higher oil resistance for films manufactured from WS up to 91 % using 4 % gelatin concentration. The morphological structure of the gelatin film was investigated with scanning electron microscopy (SEM). A homogenized and smooth film surface was observed. The percentage of heavy metal was examined by inductively coupled plasma (ICP). The results of this study showed that the films manufactured using higher concentrations of gelatin possessed promising mechanical properties, good barrier properties, and high safety as a recommended biopolymer packaging material for food contact and pharmaceutical applications.

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“…[146,147] In other mechanisms, pre-polymers are used as healing agents, polymerizing as the material is leaked in the cracks. [148,149] In our study, Calcium Carbonate (CaCO 3 ) was selected as the healing agent because of its low price and availability, [150][151][152][153][154] being one of the most used agents in researches about the subject. [155][156][157][158][159] Gelatin, poly(vinyl alcohol) (PVA) and poly(hydroxypropyl methacrylate) (PHPMA) also were chosen due to their low price and availability.…”

Section: Introductionmentioning

confidence: 99%

“…In our study, Calcium Carbonate (CaCO 3 ) was selected as the healing agent because of its low price and availability, [ 150–154 ] being one of the most used agents in researches about the subject. [ 155–159 ] Gelatin, poly(vinyl alcohol) (PVA) and poly(hydroxypropyl methacrylate) (PHPMA) also were chosen due to their low price and availability.…”

Section: Introductionmentioning

confidence: 99%

Novel Core‐Shell System Based on Gelatin and Hydrophilic Polymers Useful as Concrete Self‐healing Systems

Costa

Souza

Sousa

et al. 2021

Macromolecular Symposia

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Concrete structures repair results in substantial economic and environmental issues. So, new technologies able to increase concrete lifetime are being developed. Among them, the self-healing mechanisms, which can be improved by using polymers. Thus, three different materials are synthesized to act as self-healing systems. They are: (I) cross-linked gelatin mixed with CaCO 3 (the self-healing agent); (II) a core-shell system based on the material I layered by poly(hydroxypropyl methacrylate); and (III) a second core-shell structure based on the material I covered with poly(vinyl alcohol). Cross-linking and grafting are performed using glutaraldehyde. Fourier-transform infrared spectroscopy (FTIR) proves the structure obtaining. Thermogravimetric analysis and differential scanning calorimetry prove that the materials show thermal properties that allow their use in concrete applications. Swelling degree shows that all materials swell when in contact with water. Granulometry shows the materials are mostly in the millimeter scale. Last, an aqueous media release test shows that the three tested systems did not liberate significant amounts of CaCO 3 . Therefore, both the gelatin and gelatin + polymer systems can protect the healing material, avoiding the release of the self-healing agent before the concrete cracking takes place.

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Gelatin Paste as an Alternative Cost-Effective Hemostatic Agent in Cranial Surgery: Doing More with Less

Cited by 10 publications

References 10 publications

The role of hemostatic devices in neurosurgery. A systematic review

The role of hemostatic devices in neurosurgery. A systematic review

Efficient Eco-Friendly Nano-Extracted Gelatin as Biodegradable Packaging Material

Novel Core‐Shell System Based on Gelatin and Hydrophilic Polymers Useful as Concrete Self‐healing Systems

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