Gelatinized‐core liposomes: Toward a more robust carrier for hydrophilic molecules

Abstract

The use of liposomes as a delivery system for hydrophobic and hydrophilic drugs is well recognized. However, they possess several limitations that remained unresolved, including stability problems, low entrapment of the hydrophilic drugs, and the subsequent rapid release. This study introduces a novel approach to incorporate gelatin in the liposomal core to overcome these limitations. A rheological study was conducted to select suitable masses of the gelatin used in the liposomal formulations. Moreover, a full-factorial experimental design was utilized to compare the newly produced gel-core liposomes to the conventional liposomes with respect to the amount of a model hydrophilic molecule loading. An advanced machine learning method, namely, artificial neural networks was utilized to capture the effects of gelatin and cholesterol incorporation in the liposomes on the entrapment efficiency. The results revealed the successful preparation of the novel vesicles and their superiority over the conventional liposomes in drug loading, sustaining the drug release and stability which pose the newly introduced liposomal system as a successful delivery carrier for hydrophilic molecules and drugs. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3086-3092, 2017.

Augmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes

“…These deformations confirm the gelation of the core as the gelatin is present below its melting point (T m ) in the gel state. 53 The darker hydrophilic core is due to the concentration of the hydrophilic dye, phosphotungstic acid, in the aqueous domain. 21 , 59 , 60

Figure 2 Transmission electron micrograph (TEM) of the selected formulations, ( A ) GLG1, ( B ) GLG4 and ( C ) GL12.

…”

The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes

“…The presence of CH is associated with a significant (p < 0.05) increase in %EE from 72.3 ± 1.87% to 76.2 ± 1.36%, which is accredited to the ability of CH to enhance the hydrophobicity, rigidity and stability of the lipid bilayer with a subsequent decrease in the drug leakage from the vesicles [23,29,31].…”

“…The percent entrapment efficiency (%EE) was determined using the direct method [23]. Formulations were subjected to centrifugation at 15,000 rpm for 1 h to separate the free unentrapped drug, and the clear supernatant was discarded.…”

Optimization of Hyaluronate-Based Liposomes to Augment the Oral Delivery and the Bioavailability of Berberine

“…Catalan-Latorre et al formulated eudragit and hyaluronan liposomes to ameliorate the gastro-enteric the bioavailability and stability of curcumin [ 19 ]. Hathout et al formulated gelatinized core liposomes to decrease hydrophilic drug leakage and to increase liposomes stability [ 20 ].…”