Polymeric scale inhibitors are widely utilized in the oil and gas field because of their enhanced thermal stability and better environmental compatibility. However, the squeeze efficiency of such threshold inhibitors, not only polymeric scale inhibitors but also phosphonates, is typically poor in conventional squeeze treatment. In this research, nanoparticle cross-linked polymeric scale inhibitors were developed for scale control. Nearly monodispersed boehmite (ɤ-AlO(OH)) nanoparticles (NPs) with average size of 2.8 nm were synthesized and used to cross-link sulphonated polycarboxylic acid (SPCA). Cross-linked AlOOH-SPCA nanoinhibitors were produced and developed to increase the retention of SPCA in formations by converting liquid phase polymeric scale inhibitors into a viscous gel. Sorption study of SPCA onto AlOOH NPs under different pHs with and without assistance of Ca 2+ was discussed. In addition, sorption study of various types of scale inhibitors (SPCA, PPCA and DTPMP) onto AlOOH NPs was also performed. Squeeze simulation of neat 3% SPCA, AlOOH(3%)-SPCA(3%) NPs and AlOOH(3%)-SPCA(3%)-Ca NPs were investigated. The results showed that the addition of Ca 2+ ions improve the squeeze performance of SPCA and the normalized squeeze life of such material (8,952 bbl/Kg) was improved more than 60 times compared to that of SPCA alone (152 bbl/Kg).