Gelsolin in Onychophora and Tardigrada with notes on its variability in the Ecdysozoa

Prasath, Thiruketheeswaran; Greven, Hartmut; D’Haese, Jochen

doi:10.1016/j.cbpb.2016.09.003

Cited by 3 publications

(2 citation statements)

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“…And although tardigrades likely lost major body regions that were present in ancestors, the developmental and evolutionary mechanisms that led to such losses are incompletely understood. Tardigrades will likely continue to be useful along with other organisms to help trace evolutionary changes in the arthropods and nematodes, and more generally to aid in establishing the gene complement, development, and morphology of ancestors at various nodes of animal phylogeny (see for example Bavan et al, 2009;Hering and Mayer, 2014;Gross and Mayer, 2015;Thiruketheeswaran et al, 2016;Hering et al, 2016;Nelson, 2017;Smith et al, 2017;Koziol, 2018;Mapalo et al, 2020).…”

Section: Unanswered Questions and Future Prospectsmentioning

confidence: 99%

Tardigrades and Their Emergence as Model Organisms

Goldstein¹

2022

Preprint

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Experimentally tractable organisms like C. elegans, Drosophila, zebrafish, and mouse are popular models for addressing diverse questions in biology. In 1997, two of the most valuable invertebrate model organisms to date – C. elegans and Drosophila – were found to be much more closely related to each other than expected. C. elegans and Drosophila belong to the nematodes and arthropods respectively, and these two phyla and six other phyla make up a clade of molting animals referred to as the Ecdysozoa. The other ecdysozoan phyla could be valuable models for comparative biology, taking advantage of the rich and continual sources of research findings as well as tools from both C. elegans and Drosophila. But when the Ecdysozoa was first recognized, few tools were available for laboratory studies in any of these six other ecdysozoan phyla. In 1999 I began an effort to develop tools for studying one such phylum, the tardigrades. Here, I describe how the tardigrade species Hypsibius exemplaris and tardigrades more generally have emerged over the past two decades as valuable new models for answering diverse questions. To date, these questions have included how animal body plans evolve and how biological materials can survive some remarkably extreme conditions.

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Section: Unanswered Questions and Future Prospectsmentioning

confidence: 99%

Tardigrades and Their Emergence as Model Organisms

Goldstein¹

2022

Preprint

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“…Studies using this model and the other tardigrade species mentioned above have focused mostly on survival in extreme conditions in the laboratory (Guidetti et al 2011;Horikawa et al 2013;Beltrán-Pardo et al 2015;Fernandez et al 2016;Vasanthan et al 2017), identifying extremotolerance mechanisms (Kondo et al 2015;Hashimoto et al 2016;Boothby et al 2017), development and anatomy and the evolution of development and anatomy Mayer et al 2013;Smith and Jockusch 2014;Gross and Mayer 2015;Hyra et al 2016a,b;Smith et al 2016;Gross et al 2017), taxonomic methods and relationships (Rota-Stabelli et al 2010;Stec et al 2016), sequence comparisons with other species (Förster et al 2009;Mali et al 2010;Christie et al 2011;D'Haese et al 2011;Beltrán-Pardo et al 2013;Hering and Mayer 2014;Mayer et al 2015;Szitenberg et al 2016;Thiruketheeswaran et al 2017;Nelson 2018), and analyses of specific proteins (Bavan et al 2009;Hering et al 2016). Genomic studies are discussed in a section below.…”

Section: Uses Of the H Exemplaris Model Systemmentioning

confidence: 99%

The Emergence of the TardigradeHypsibius exemplarisas a Model System

Goldstein

2018

Cold Spring Harb Protoc

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The success of scientists in revealing biological mechanisms has depended in large part on choosing tractable model systems. In 1997, molecular phylogenetics revealed that two of biology's most tractable models-Caenorhabditis elegans and Drosophila-are much more closely related to each other than had been thought previously. I began to explore whether any of the little-studied members of this branch of the tree of life might serve as a new model for comparative biology that could make use of the rich and ongoing sources of information flowing from C. elegans and Drosophila research. Tardigrades, also known as water bears, make up a phylum of microscopic animals. The tardigrade Hypsibius exemplaris (recently disambiguated from a closely related species, Hypsibius dujardini) can be maintained in laboratories and has a generation time of <2 wk at room temperature. Stocks of animals can be stored frozen and revived. The animals and their embryos are optically clear, and embryos are laid in groups, with each synchronous clutch of embryos laid in a clear molt. We have developed techniques for laboratory study of this system, including methods for microinjection of animals, immunolocalization, in situ hybridization, RNA interference, transcriptomics, and methods for identifying proteins that mediate tolerance to extreme environments. Here, I review the development of this animal as an emerging model system, as well as recent molecular studies aimed at understanding the evolution of developmental mechanisms that underpin the evolution of animal form and at understanding how biological materials can survive extreme environments.

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Tardigrades and their emergence as model organisms

Goldstein

2022

Current Topics in Developmental Biology

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Gelsolin in Onychophora and Tardigrada with notes on its variability in the Ecdysozoa

Cited by 3 publications

References 35 publications

Tardigrades and Their Emergence as Model Organisms

Tardigrades and Their Emergence as Model Organisms

The Emergence of the TardigradeHypsibius exemplarisas a Model System

Tardigrades and their emergence as model organisms

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